한빛사논문
- 조회264
Hyung-Taeg Cho 1,*, Minsu Lee 1, Hee-Seung Choi 1, Kwang-Ho Maeng 1, Kyeonghoon Lee 1, Ha-Yeon Lee 1, Anindya Ganguly 1, Hoonyoung Park 2, and Chang-Hoi Ho 2
1Department of Biological Sciences, Seoul National University, Seoul, Korea
2School of Earth and Environmental Sciences, Seoul National University, Seoul, Korea
*Corresponding author: correspondence to Hyung-Taeg Cho
Abstract
Combinatorial interactions between different regulators diversify and enrich the chance of transcriptional regulation in eukaryotic cells. However, a dose-dependent functional switch of homologous transcriptional repressors has rarely been reported. Here, we show that SHY2, an Auxin/Indole-3-Acetic Acid (Aux/IAA) repressor, exhibits a dose-dependent bimodal role in auxin-sensitive root-hair growth and gene transcription in Arabidopsis, whereas other Aux/IAA homologs consistently repress the auxin responses. The corepressor (TOPLESS [TPL])-binding affinity of a bimodal Aux/IAA was lower than that of a consistently repressing Aux/IAA. The switch of a single amino-acid residue in the TPL-binding motif between the bimodal form and the consistently repressing form switched their TPL-binding affinity and transcriptional and biological roles in auxin responses. Based on these data, we propose a model whereby competition between homologous repressors with different corepressor-binding affinities could generate a bimodal output at the transcriptional and developmental levels.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-08-02)
- 국내 연구진
- 생명과학 > 분자생물학
관련 보도자료
- Bio통신원
- 2024. 08. 08
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