배은솔 (동아대학교)

한빛사논문

조회105

동아대학교

CV File 96 kb

J. Hazard. Mater., Jul 15 2024, 476 S0304-3894(24)01793-X | https://doi.org/10.1016/j.jhazmat.2024.135214 The oxidative stress-dependent pulmonary inflammation of inhalable multi-walled carbon nanotube-containing nano-concrete dust and its comparison with conventional concrete dust and DQ12

Eunsol Bae^a,1, Songyeon Kim ^a,1, Jae Hyuck Sung^b, Joo Hyung Kim ^c, Sang Hwa Jung ^c, Kyung-Seuk Song ^b, Wan-Seob Cho^a

^aLab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Republic of Korea

^bBio Division, Korea Conformity Laboratories, Incheon 21999, Republic of Korea

^cConstruction Division, Korea Conformity Laboratories, Cheongju 28115, Republic of Korea

¹These authors contributed equally to this work.

Correspondence to: Wan-Seob Cho

Abstract

Nano-concrete, which is an admixture of nanomaterials in concrete recipes, has been investigated to overcome the limitations of existing concrete, such as its stability and strength. However, there is no information on the human health effects of broken-down dust released during the construction and demolition efforts. In this study, we prepared an inhalable fraction of multi-walled carbon nanotube-containing nano-concrete dust and performed comparative toxicity studies with conventional concrete dust and DQ12 using a rat intratracheal instillation model. Although the recipes for concrete and nano-concrete are entirely different, the pulverized dust samples showed similar physicochemical properties, such as 0.46-0.48 µm diameter and chemical composition. Both concrete and nano-concrete dust exhibited similar patterns and magnitudes, representing acute neutrophilic inflammation and chronic active inflammation with lymphocyte infiltration. The toxicity endpoints of the tested particles at both time points showed an excellent correlation with the reactive oxygen species levels released from the alveolar macrophages, highlighting that alveolar macrophages are the primary target cells and that the oxidative stress paradigm is the main toxicity mechanism of the tested particles. In addition, the toxicity potentials of both concrete and nano-concrete dust were more than 10 times lower than that of DQ12.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-08-05)
연구진국내 연구진
분야 의약학 > 응용의학

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