한빛사논문
- 조회104
Jiwoong Choi1, Hochung Jang1,2, Daeho Park1,3, Byeongmin Park1,4, Yeongji Jang1,3, Sangmin Lee4, Sun Hwa Kim1,5, Man Kyu Shim,1* and Yoosoo Yang1,2*
1Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
2Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea
3Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea
4College of Pharmacy, Graduate School of Pharmaceutical Sciences, Kyung Hee University, Seoul 02453, Republic of Korea
5KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea
Corresponding Authors : Yoosoo Yang, Man Kyu Shim
Abstract
Most orally administered drugs struggle to reach intracerebral regions due to the intestinal epithelial barrier (IEB) and blood–brain barrier (BBB). In this study, we investigate the potential of milk-derived exosomes (mExos) as a noninvasive solution to overcome both barriers, facilitating photodynamic therapy (PDT) of the glioblastoma. By leveraging the inherent properties of mExos, our goal is to ensure optimal efficacy by delivering a concentrated dose of the photosensitizer to the desired region. In this context, we developed photoresponsive mExos loaded with the photosensitizer chlorin e6 (Ce6@mExo) for glioblastoma treatment. Intriguingly, our findings reveal that Ce6@mExo effectively traverses both the IEB and the BBB following oral administration, significantly accumulating in brain tissue. This enhanced accumulation correlates with substantial tumor cell death in a glioblastoma orthotopic model upon laser irradiation. Our study underscores the promise of milk exosomes as vehicles for brain drug delivery via oral administration, enhancing patient convenience and therapeutic efficacy.
논문정보
- Research article
- 2024년 07월 (BRIC 등록일 2024-08-01)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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