윤주영 (이화여자대학교)

한빛사논문

조회55

이화여자대학교

Adv. Healthc. Mater., Jul 28 2024, | https://doi.org/10.1002/adhm.202401981 Harnessing Dual Phototherapy and Immune Activation for Cancer Treatment: The Development and Application of BODIPY@F127 Nanoparticles

Yang Peng ¹, Chenyan Hu ², Ludan Zhang ¹, Fan Dong ¹, Ruwan Li ², Huihui Liang ³, Hao Dai ¹, Won Jun Jang ⁴, Hong-Bo Cheng ², Liming Zhou ³, Yuguang Wang ¹, Juyoung Yoon ⁴

¹Department of General Dentistry II, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No.22, Zhongguancun South Avenue Haidian District, Beijing, 100081, P. R. China.

²State Key Laboratory of Organic-Inorganic Composites, Key Lab of Biomedical Materials of Natural Macromolecules, Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, 15 North Third Ring Road, Beijing, 100029, P. R. China.

³Henan Provincial Key Laboratory of Surface & Interface Science, School of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou, 450002, China.

⁴Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, South Korea.

Y.P. and C.H. contributed equally to this work.

Corresponding Authors: Hong-Bo Cheng, Liming Zhou, Yuguang Wang, Juyoung Yoon

Abstract

Conventional phototherapeutic agents are typically used in either photodynamic therapy (PDT) or photothermal therapy (PTT). However, efficacy is often hindered by hypoxia and elevated levels of heat shock proteins in the tumor microenvironment (TME). To address these limitations, a formylated, near-infrared (NIR)-absorbing and heavy-atom-free Aza-BODIPY dye is presented that exhibits both type-I and type-II PDT actions with a high yield of reactive oxygen species (ROS) and manifests efficient photothermal conversion by precise adjustments to the conjugate structure and electron distribution, leading to a large amount of ROS production even under severe hypoxia. To improve biosafety and water solubility, the dye with an amphiphilic triblock copolymer (Pluronic F-127), yielding BDP-6@F127 nanoparticles (NPs) is coated. Furthermore, inspired by the fact that phototherapy triggers the release of tumor-associated antigens, a strategy that leverages potential immune activation by combining PDT/PTT with immune checkpoint blockade (ICB) therapy to amplify the systemic immune response and achieve the much-desired abscopal effect is developed. In conclusion, this study presents a promising molecular design strategy that integrates multimodal therapeutics for a precise and effective approach to cancer therapy.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-08-09)
연구진국내(교신)+국외 연구진
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