한빛사논문
- 조회97
단국대학교
Ga Ram Yang, Woojin Kim, Jae Hwan Jung
Department of Pharmaceutical Engineering, Dankook University, Cheonan, South Korea
Corresponding author : Jae Hwan Jung
Abstract
Diabetes is a chronic disease with significant complications, necessitating regular treatment and checkups, which can be costly and time-consuming for patients. To address this, we developed the Sliding Microneedle (MN)-Lateral flow immunoassay strip (LFIAs) device that combines the advantages of MNs and LFIAs to detect IL-6, an independent biomarker for diabetes complications. This device offers rapid and highly sensitive detection of IL-6 by extracting interstitial fluid (ISF) through MNs and transferring it to LFIAs. The stainless MN, embedded in the 3D-printed Sliding MN-LFIAs device, was inserted into the skin at a 20° angle, minimizing blood contamination risk. With a filter paper attached to the MN surface, the device collected 4.65 ± 0.05 μL of ISF containing IL-6 within 90 seconds. The ISF was then transferred to the LFIAs using a running buffer. After a 15-minute reaction, silver enhancement (SE) treatment was applied, allowing for the highly sensitive and specific detection of IL-6 at 102 pg/mL concentrations. The Sliding MN-LFIAs device successfully distinguished between normal and diabetic rat models, demonstrating its potential as an effective tool for detecting diabetes complications quickly and affordably.
논문정보
- Research article
- 2024년 07월 (BRIC 등록일 2024-08-09)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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