한빛사논문
- 조회275
Tejal V. Patil a,b,1, Hexiu Jin c,1, Sayan Deb Dutta a,e, Rumi Aacharya a,b, Kehan Chen c, Keya Ganguly a,d, Aayushi Randhawa a,b, Ki-Taek Lim a,b,d
aDepartment of Biosystems Engineering, Kangwon National University, Chuncheon-24341, Republic of Korea
bInterdisciplinary Program in Smart Agriculture, Kangwon National University, Chuncheon-24341, Republic of Korea
cDepartment of Plastic and Traumatic Surgery, Capital Medical University, Beijing-10096, China
dInstitute of Forest Science, Kangwon National University, Chuncheon-24341, Republic of Korea
eCenter for Surgical Bioengineering, Department of Surgery, School of Medicine, University of California Davis, Sacramento, California-95817, United States
1Authors contributed equally to this manuscript.
Corresponding author : Ki-Taek Lim
Abstract
Rapid regeneration of the injured tissue or organs is necessary to achieve the usual functionalities of the damaged parts. However, bacterial infections delay the regeneration process, a severe challenge in the personalized healthcare sector. To overcome these challenges, 3D-printable multifunctional hydrogels of Zn/tannic acid-reinforced glycol functionalized chitosan for rapid wound healing were developed. Polyphenol strengthened intermolecular connections, while glutaraldehyde stabilized 3D-printed structures. The hydrogel exhibited enhanced viscoelasticity (G′; 1.96 × 104 Pa) and adhesiveness (210 kPa). The dual-crosslinked scaffolds showed remarkable antibacterial activity against Bacillus subtilis (∼81 %) and Escherichia coli (92.75 %). The hydrogels showed no adverse effects on human dermal fibroblasts (HDFs) and macrophages (RAW 264.7), indicating their superior biocompatibility. The Zn/TA-reinforced hydrogels accelerate M2 polarization of macrophages through the activation of anti-inflammatory transcription factors (Arg-1, VEGF, CD163, and IL-10), suggesting better immunomodulatory effects, which is favorable for rapid wound regeneration. Higher collagen deposition and rapid re-epithelialization occurred in scaffold-treated rat groups vis-à-vis controls, demonstrating superior wound healing. Taken together, the developed multifunctional hydrogels have great potential for rapidly regenerating bacteria-infected wounds in the personalized healthcare sector.
논문정보
- Research article
- 2024년 07월 (BRIC 등록일 2024-07-25)
- 국내 연구진
- 바이오·의료융합 > 다학제 융합/복합
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