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Max-Planck-Institute for Molecular Biomedicine

Cell Stem Cell, July 23, 2024 | https://doi.org/10.1016/j.stem.2024.06.015 Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling

Rui Chen,¹ Rui Fan,¹ Fei Chen,¹ Niraimathi Govindasamy,¹ Heike Brinkmann,¹ Martin Stehling,² Ralf H. Adams,³ Hyun-Woo Jeong,^3,4,* and Ivan Bedzhov^1,5,*

¹Embryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149 Munster, Germany

²Flow Cytometry Unit, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149 Munster, Germany

³Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149 Munster, Germany

⁴Single Cell Multi-Omics Laboratory, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149 Munster, Germany

⁵Lead contact

^*Correspondence: Hyun-Woo Jeong, Ivan Bedzhov

Abstract

Embryonic diapause is a reproductive adaptation that enables some mammalian species to halt the otherwise continuous pace of embryonic development. In this dormant state, the embryo exploits poorly understood regulatory mechanisms to preserve its developmental potential for prolonged periods of time. Here, using mouse embryos and single-cell RNA sequencing, we molecularly defined embryonic diapause at single-cell resolution, revealing transcriptional dynamics while the embryo seemingly resides in a state of suspended animation. Additionally, we found that the dormant pluripotent cells rely on integrin receptors to sense their microenvironment and preserve their viability via Yap/Taz-mediated prosurvival signaling.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-07-24)
연구진국외 연구진
분야 생명과학 > 발생생물학

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