한빛사논문
- 조회145
Seung-Won Jung 1,2, Jae Joon Jeon 1,2, You Hyun Kim 1, Sung Jay Choe 1,* & Solam Lee 1,*
1Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
2These authors contributed equally: Seung-Won Jung, Jae Joon Jeon.
*Corresponding authors: correspondence to Sung Jay Choe or Solam Lee
Abstract
The long-term association between mRNA-based coronavirus disease 2019 (COVID-19) vaccination and the development of autoimmune connective tissue diseases (AI-CTDs) remains unclear. In this nationwide, population-based cohort study involving 9,258,803 individuals, we aim to determine whether the incidence of AI-CTDs is associated with mRNA vaccination. The study spans over 1 year of observation and further analyses the risk of AI-CTDs by stratifying demographics and vaccination profiles and treating booster vaccination as time-varying covariate. We report that the risk of developing most AI-CTDs did not increase following mRNA vaccination, except for systemic lupus erythematosus with a 1.16-fold risk in vaccinated individuals relative to controls. Comparable results were reported in the stratified analyses for age, sex, mRNA vaccine type, and prior history of non-mRNA vaccination. However, a booster vaccination was associated with an increased risk of some AI-CTDs including alopecia areata, psoriasis, and rheumatoid arthritis. Overall, we conclude that mRNA-based vaccinations are not associated with an increased risk of most AI-CTDs, although further research is needed regarding its potential association with certain conditions.
논문정보
- Research article
- 2024년 07월 (BRIC 등록일 2024-07-23)
- 국내 연구진
- 의약학 > 면역의학
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