윤유석 (성균관대학교)

한빛사논문

조회215

성균관대학교

CV File 115 kb

Adv. Drug Deliv. Rev., Jul 18 2024, S0169-409X(24)00233-3 | https://doi.org/10.1016/j.addr.2024.115411 Precise subcellular targeting approaches for organelle-related disorders

Gayong Shim ^a, Yu Seok Youn ^b

^aSchool of Systems Biomedical Science and Integrative Institute of Basic Sciences, Soongsil University, Seoul 06978, Republic of Korea

^bSchool of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea

Corresponding author: Yu Seok Youn

Abstract

Pharmacological research has expanded to the nanoscale level with advanced imaging technologies, enabling the analysis of drug distribution at the cellular organelle level. These advances in research techniques have contributed to the targeting of cellular organelles to address the fundamental causes of diseases. Beyond navigating the hurdles of reaching lesion tissues upon administration and identifying target cells within these tissues, controlling drug accumulation at the organelle level is the most refined method of disease management. This approach opens new avenues for the development of more potent therapeutic strategies by delving into the intricate roles and interplay of cellular organelles. Thus, organelle-targeted approaches help overcome the limitations of conventional therapies by precisely regulating functionally compartmentalized spaces based on their environment. This review discusses the basic concepts of organelle targeting research and proposes strategies to target diseases arising from organelle dysfunction. We also address the current challenges faced by organelle targeting and explore future research directions.

논문정보

형식Review Paper
게재일2024년 07월 (BRIC 등록일 2024-07-23)
연구진국내 연구진
분야 의약학 > 약학

댓글 작성 로그인

CV 열람하기

연락처 보기