Fahad Hassan Shah (조선대학교 약학대학)

한빛사논문

조회110

Fahad Hassan ShahFahad Hassan Shah

조선대학교 약학대학

Cytokine Growth Factor Rev., Jul 14 2024, S1359-6101(24)00048-0 | https://doi.org/10.1016/j.cytogfr.2024.07.005 Endothelial and macrophage interactions in the angiogenic niche

Fahad Hassan Shah, Heon-Woo Lee

College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea

Corresponding author : Heon-Woo Lee

Abstract

The interactions between vascular cells, especially endothelial cells, and macrophages play a pivotal role in maintaining the subtle balance of vascular biology, which is crucial for angiogenesis in both healthy and diseased states. These cells are central to ensuring a harmonious balance between tissue repair and preventing excessive angiogenic activity, which could lead to pathological conditions. Recent advances in sophisticated genetic engineering vivo models and novel sequencing approaches, such as single-cell RNA-sequencing, in immunobiology have significantly enhanced our understanding of the gene expression and behavior of macrophages. These insights offer new perspectives on the role macrophages play not only in development but also across various health conditions. In this review, we explore the complex interactions between multiple types of macrophages and endothelium, focusing on their impact on new blood vessel formation. By understanding these intricate interactions, we aim to provide insights into new methods for managing angiogenesis in various diseases, thereby offering hope for the development of novel therapeutic approaches.

논문정보

형식Review Paper
게재일2024년 07월 (BRIC 등록일 2024-07-19)
연구진국내 연구진
분야 생명과학 > 유전학

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