진준오 (울산대학교 의과대학, 서울아산병원)

한빛사논문

조회187

울산대학교 의과대학, 서울아산병원

CV File 427 kb

J. Control. Release, Jul 12 2024, 373 S0168-3659(24)00451-6 | https://doi.org/10.1016/j.jconrel.2024.07.020 Lipid-coated gold nanorods for photoimmunotherapy of primary breast cancer and the prevention of metastasis

So-Jung Kim ^a, Hae-Bin Park^a, Eun-Koung An ^a, Dayoung Ryu ^b, Wei Zhang^c, Chan-Gi Pack ^d, HyunCheol Kim^e, Minseok Kwak ^f, Wonpil Im^g, Ja-Hyoung Ryu ^h, Peter C.W. Lee ^b, Jun-O Jin ^a

^aDepartment of Microbiology, Brain Korea 21 Project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul 05505, South Korea

^bDepartment of Biochemistry and Molecular Biology, Brain Korea 21 Project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul 05505, South Korea

^cShanghai Public Health Clinical Center, Fudan University, Shanghai 200437, China

^dDepartment of Biomedical Engineering, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea

^eDepartment of Chemical and Biomolecular Engineering Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, South Korea

^fDepartment of Chemistry, Pukyong National University, Busan 48513, South Korea

^gDepartment of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA

^hDepartment of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, South Korea

Corresponding authors : Peter C.W. Lee, Jun-O Jin

Abstract

Nanomedicines hold promise for the treatment of various diseases. However, treating cancer metastasis remains highly challenging. In this study, we synthesized gold nanorods (AuNRs) containing (α-GC), an immune stimulator, for the treatment of primary cancer, metastasis, and recurrence of the cancer. Therefore, the AuNR were coated with lipid bilayers loaded with α-GC (α-LA). Upon irradiation with 808 nm light, α-LA showed a temperature increase. Intra-tumoral injection of α-LA in mice and local irradiation of the 4T1 breast cancer tumor effectively eliminated tumor growth. We found that the presence of α-GC in α-LA activated dendritic cells and T cells in the spleen, which completely blocked the development of lung metastasis. In mice injected with α-LA for primary breast cancer treatment, we observed antigen-specific T cell responses and increased cytotoxicity against 4T1 cells. We conclude that α-LA is promising for the treatment of both primary breast cancer and its metastasis.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-07-15)
연구진국내(교신)+국외 연구진
분야 의약학 > 면역의학

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