황석연 (서울대학교)

한빛사논문

조회131

서울대학교

CV File 301 kb

Adv. Healthc. Mater., Jul 11 2024, | https://doi.org/10.1002/adhm.202400170 Electrical Stimulating Redox Membrane Incorporated with PVA/Gelatin Nanofiber for Diabetic Wound Healing

Jeong-Uk Kim¹, Junghyeon Ko ¹, Ye-Sol Kim ¹, Minwoong Jung ², Myoung-Hoon Jang ², Young-Hyeon An³, Nathaniel S. Hwang ^1,3,4

¹School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

²Biosensor Laboratories Inc, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea.

³BioMax/N-Bio Institute, Seoul National University, Seoul, 08826, Republic of Korea.

⁴Institute of Engineering Research, Seoul National University, Seoul, 08826, Republic of Korea.

CORRESPONDING AUTHORS: Young-Hyeon An, Nathaniel S. Hwang

Abstract

Chronic wounds adversely affect the quality of life. Although electrical stimulation has been utilized to treat chronic wounds, there are still limitations to practicing it due to the complicated power system. Herein, an electrostimulating membrane incorporated with electrospun nanofiber (M-sheet) to treat diabetic wounds is developed. Through the screen printing method, the various alternate patterns of both Zn and AgCl on a polyurethane substrate, generating redox-mediated electrical fields are introduced. The antibacterial ability of the patterned membrane against both E. coli and S. aureus is confirmed. Furthermore, the poly(vinyl alcohol) (PVA)/gelatin electrospun fiber is incorporated into the patterned membrane to enhance biocompatibility and maintain the wet condition in the wound environment. The M-sheet can improve cell proliferation and migration in vitro and has an immune regulatory effect by inducing the polarization of macrophage to the M2 phenotype. Finally, when applied to a diabetic skin wound model, the M-sheet displays an accelerated wound healing rate and enhances re-epithelialization, collagen synthesis, and angiogenesis. It suggests that the M-sheet is a simple and portable system for the spontaneous generation of electrical stimulation and has great potential to be used in the practical wound and other tissue engineering applications.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-07-15)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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