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- 조회148
Semin. Immunopathol., Jul 11 2024, 46 (1-2) | https://doi.org/10.1007/s00281-024-01012-x
Gut microbiota-derived metabolites tune host homeostasis fate
Seungil Kim1,2, Sang‑Uk Seo3, Mi‑Na Kweon1,2
1Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine / Asan Medical Center, Seoul, Republic of Korea
2Digestive Diseases Research Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
3Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Contact : Mi-Na Kweon
Abstract
The gut microbiota, housing trillions of microorganisms within the gastrointestinal tract, has emerged as a critical regulator of host health and homeostasis. Through complex metabolic interactions, these microorganisms produce a diverse range of metabolites that substantially impact various physiological processes within the host. This review aims to delve into the intricate relationships of gut microbiota-derived metabolites and their influence on the host homeostasis. We will explore how these metabolites affect crucial aspects of host physiology, including metabolism, mucosal integrity, and communication among gut tissues. Moreover, we will spotlight the potential therapeutic applications of targeting these metabolites to restore and sustain host equilibrium. Understanding the intricate interplay between gut microbiota and their metabolites is crucial for developing innovative strategies to promote wellbeing and improve outcomes of chronic diseases.
논문정보
- Review Paper
- 2024년 07월 (BRIC 등록일 2024-07-15)
- 국내 연구진
- 의약학 > 면역의학
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