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Bioact. Mater., 2024 Jun 15:40:345-365 | https://doi.org/10.1016/j.bioactmat.2024.06.022
Fostering tissue engineering and regenerative medicine to treat musculoskeletal disorders in bone and muscle
Soyeon Park a,b,1, Khandoker Asiqur Rahaman a,1, Yu-Chan Kim a,c, Hojeong Jeon a,b, Hyung-Seop Han a,c
aBiomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea
bKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea
cDivision of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea
Corresponding authors: Hojeong Jeon, Hyung-Seop Han
Abstract
The musculoskeletal system, which is vital for movement, support, and protection, can be impaired by disorders such as osteoporosis, osteoarthritis, and muscular dystrophy. This review focuses on the advances in tissue engineering and regenerative medicine, specifically aimed at alleviating these disorders. It explores the roles of cell therapy, particularly Mesenchymal Stem Cells (MSCs) and Adipose-Derived Stem Cells (ADSCs), biomaterials, and biomolecules/external stimulations in fostering bone and muscle regeneration. The current research underscores the potential of MSCs and ADSCs despite the persistent challenges of cell scarcity, inconsistent outcomes, and safety concerns. Moreover, integrating exogenous materials such as scaffolds and external stimuli like electrical stimulation and growth factors shows promise in enhancing musculoskeletal regeneration. This review emphasizes the need for comprehensive studies and adopting innovative techniques together to refine and advance these multi-therapeutic strategies, ultimately benefiting patients with musculoskeletal disorders.
논문정보
- Review Paper
- 2024년 06월 (BRIC 등록일 2024-07-10)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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