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이민규Mingyu Lee

광주과학기술원

Bioact. Mater., Available online 14 June 2024 | https://doi.org/10.1016/j.bioactmat.2024.06.017 Wet tissue adhesive polymeric powder hydrogels for skeletal muscle regeneration

Mingyu Lee ^a,1, Daun Seo ^a,1, Junggeon Park ^a, Sun Hong Lee^b, Jin Jeon ^b, Woochan Kim^c,d,e, Jangho Kim^c,d,e, Hee Seok Yang ^b, Jae Young Lee^a

^aSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea

^bDepartment of Nanobiomedical Science & BK21 FOUR NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 31116, Republic of Korea

^cDepartment of Convergence Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea

^dDepartment of Rural and Biosystems Engineering, Chonnam National University, Gwangju, Republic of Korea

^eInterdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju, 61186, Republic of Korea

¹These authors contributed equally.

Corresponding author : Jae Young Lee

Abstract

Volumetric muscle loss (VML) frequently results from traumatic incidents and can lead to severe functional disabilities. Hydrogels have been widely employed for VML tissue regeneration, which are unfortunately ineffective because of the lack of intimate contact with injured tissue for structural and mechanical support. Adhesive hydrogels allow for strong tissue connections for wound closure. Nevertheless, conventional adhesive hydrogels exhibit poor tissue adhesion in moist, bleeding wounds due to the hydration layer at the tissue-hydrogel interfaces, resulting in insufficient performance. In this study, we developed a novel, biocompatible, wet tissue adhesive powder hydrogel consisting of dextran-aldehyde (dex-ald) and gelatin for the regeneration of VML. This powder absorbs the interfacial tissue fluid and buffer solution on the tissue, spontaneously forms a hydrogel, and strongly adheres to the tissue via various molecular interactions, including the Schiff base reaction. In particular, the powder composition with a 1:4 ratio of dex-ald to gelatin exhibited optimal characteristics with an appropriate gelation time (258 s), strong tissue adhesion (14.5 kPa), and stability. Dex-ald/gelatin powder hydrogels presented strong adhesion to various organs and excellent hemostasis compared to other wet hydrogels and fibrin glue. A mouse VML injury model revealed that the dex-ald/gelatin powder hydrogel significantly improved muscle regeneration, reduced fibrosis, enhanced vascularization, and decreased inflammation. Consequently, our wet-adhesive powder hydrogel can serve as an effective platform for repairing various tissues, including the heart, muscle, and nerve tissues.

논문정보

형식Research article
게재일2024년 06월 (BRIC 등록일 2024-07-11)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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