이상진 (서울대학교병원)

한빛사논문

조회149

서울대학교병원

Mol. Psychiatr., Jul 07 2024, | https://doi.org/10.1038/s41380-024-02650-1 The risks for major psychiatric disorders in the siblings of probands with major depressive disorder

Sang Jin Rhee¹, Linda Abrahamsson², Jan Sundquist^2,3, Kristina Sundquist^2,3,6 and Kenneth S. Kendler^4,5,6

¹Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.

²Center for Primary Health Care Research, Lund University, Malmö, Sweden.

³Department of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

⁴Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.

⁵Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.

⁶These authors contributed equally: Kristina Sundquist, Kenneth S. Kendler.

Corresponding author

Correspondence to Kenneth S. Kendler.

Abstract

Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970-1990 and followed through 2018, we sought to clarify the degree to which the familial liability to MD is reflected in its clinical features, and the pattern of psychiatric disorders at elevated risk in the siblings of MD probands. The study population included full-siblings of 197,309 MD and matched 197,309 control probands. The proband-sibling tetrachoric correlation of for MD was +0.20. Both linear and quadratic effects of younger AAO and number of episodes significantly increased the risk of MD in siblings. Male sex, anxiety disorder, alcohol use disorder (AUD), inpatient treatment, psychotic symptoms, severity, and antidepressant prescription in MD probands increased the risk of MD in siblings. Cox proportional hazard models (hazard ratios, 95% CI) revealed a significantly increased risk of attention deficit hyperactivity disorder (1.82, 1.76-1.88), generalized anxiety disorder (1.79, 1.74-1.85), bipolar disorder (1.78, 1.70-1.85), MD (1.74, 1.72-1.76), obsessive-compulsive disorder (1.72, 1.65-1.80), phobic anxiety disorder (1.71, 1.65-1.76), and panic disorder (1.68, 1.64-1.72) in MD co-siblings. The HRs for AUD (1.64, 1.60-1.68), post-traumatic stress disorder (1.62, 1.59-1.66) were modestly lower, and the lowest was seen for schizophrenia (1.42, 1.30-1.54). The overall pattern of increased risk of these disorders was similar in reared-apart half-siblings and cousins of MD probands. Our findings suggest that MD is familial, and a range of important clinical factors predict its familial liability. The familial liability to MD, mostly due to genetic factors, is shared with a broad range of psychiatric disorders.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-07-09)
연구진국내+국외 연구진
분야 의약학 > 응용의학

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