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Plant Commun., Jul 05 2024, S2590-3462(24)00378-X | https://doi.org/10.1016/j.xplc.2024.101037
Crosstalk between RNA m6A modification and epigenetic factors for gene regulation in plants
Jianzhong Hu 1, Tao Xu 2, Hunseung Kang 2,3
1Guangdong Provincial Key Laboratory for Plant Epigenetics, Longhua Bioindustry and Innovation Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China,
2Jiangsu Key Laboratory of Genomics, School of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu Province 221116, China,
3Department of Applied Biology, College of Agriculture and Life Sciences, Chonnam National University, Gwangju 61186, Korea
Co-corresponding authors: Tao Xu, Hunseung Kang
Abstract
N
6-methyladenosine (m
6A) is the most abundant modification observed in eukaryotic mRNAs. Following advancements in transcriptome-wide m
6A mapping and sequencing technologies, several conserved motifs, including RRACH (R = A/G and H = A/C/U) and UGUAW (W = U or A) motifs, have been identified in plants. However, the mechanisms underlying the deposition of the m
6A marks at a specific position in the conserved motif in each transcript are primarily known. Evidence has emerged in plant and animal studies to suggest that the m
6A writer or eraser components are recruited to the specific genomic loci by interacting with particular transcription factors, 5mC DNA methylation marks, and histone marks. In addition, recent studies in animal cells have shown that microRNAs play a role in depositing m
6A marks at a specific site in a transcript via a base-pairing mechanism. Furthermore, m
6A affects the biogenesis and function of chromatin-associated regulatory RNAs and long noncoding RNAs. Although our understanding of a link between m
6A modification and epigenetic factors in plants is lower than the increased knowledge in animals, recent progress in identifying the proteins that interact with the m
6A writer or eraser components has expanded insights into the crosstalk between m
6A modification and epigenetic factors that play a crucial role in transcript-specific methylation and regulation of m
6A in plants.
논문정보
- Review Paper
- 2024년 07월 (BRIC 등록일 2024-07-08)
- 국내(교신)+국외 연구진
- 생명과학 > 식물학
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