강한창 (가톨릭대학교 약학대학)

한빛사논문

조회178

가톨릭대학교 약학대학

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Adv. Drug Deliv. Rev., Jul 04 2024, S0169-409X(24)00208-4 | https://doi.org/10.1016/j.addr.2024.115386 Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond

Hana Cho ^a,1, Kang Moo Huh ^b,1, Min Suk Shim ^c, Yong-Yeon Cho ^a,d, Joo Young Lee ^a,d, Hye Suk Lee^a,d, Young Jik Kwon ^e, Han Chang Kang^a,d

^aDepartment of Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea

^bDepartment of Polymer Science and Engineering & Materials Science and Engineering, Chungnam National University, Daejeon 34134, Republic of Korea

^cDivision of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea

^dRegulated Cell Death (RCD) Control‧Material Research Institute, The Catholic University of Korea, Bucheon 14662, Republic of Korea

^eDepartment of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USA

¹H. Cho and K.M. Huh contributed equally to this work.

Corresponding author : Han Chang Kang

Abstract

To maximize therapeutic effects and minimize unwanted effects, the interest in drug targeting to the endoplasmic reticulum (ER) or Golgi apparatus (GA) has been recently growing because two organelles are distributing hubs of cellular building/signaling components (e.g., proteins, lipids, Ca ²⁺) to other organelles and the plasma membrane. Their structural or functional damages induce organelle stress (i.e., ER or GA stress), and their aggravation is strongly related to diseases (e.g., cancers, liver diseases, brain diseases). Many efforts have been developed to image (patho)physiological functions (e.g., oxidative stress, protein/lipid-related processing) and characteristics (e.g., pH, temperature, biothiols, reactive oxygen species) in the target organelles and to deliver drugs for organelle disruption using organelle-targeting moieties. Therefore, this review will overview the structure, (patho)physiological functions/characteristics, and related diseases of the organelles of interest. Future direction on ER or GA targeting will be discussed by understanding current strategies and investigations on targeting, imaging/sensing, and therapeutic strategies.

논문정보

형식Review Paper
게재일2024년 07월 (BRIC 등록일 2024-07-09)
연구진국내(교신)+국외 연구진
분야 의약학 > 약학

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