한빛사논문
- 조회267
Hyun Kim1,2, Seonjoo Lee2,3,4, Alina Levine4, Benjamin Huber4, Howard Andrews1,3, Nancy A. Kerner1,2, Daniel Cohen2, Scott Carlson2, Sophie A. Bell2, Andres M. Rivera5, Marc L. Gordon6, Sabrina Simoes5, Davangere. P. Devanand1,2,5, Adam M. Brickman5, Lon S. Schneider7, Philip D. Harvey8, Terry E. Goldberg1,2,9
1Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA
2Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, New York, USA
3Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA
4Division of Mental Health Data Science, New York State Psychiatric Institute, New York, New York, USA
5Department of Neurology, Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Vagelos College of Physiciansand Surgeons, Columbia University, New York, New York, USA
6Departments of Neurology and Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, The Litwin-Zucker Research Center, FeinsteinInstitutes for Medical Research, Manhasset, New York, USA
7University of Southern California Keck School of Medicine, Los Angeles, California, USA
8University of Miami Miller School of Medicine, Miami VA Medical Center, Miami, Florida, USA
9Department of Anesthesiology, Columbia University Irving Medical Center, New York, New York, USA
Correspondence : Hyun Kim, Terry E. Goldberg, PhD,
Abstract
Introduction: This study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early-stage Alzheimer's disease (AD) clinical trials. Their psychometric properties and associations with AD risk markers were compared to those of well-established measures.
Methods: For 291 older adults with healthy cognition or early mild cognitive impairment, Exploratory factor analyses were used to identify the factor structure of the NPE. Factor and total scores were examined for their psychometric properties and associations with AD risk biomarkers.
Results: Composite scores from the novel cognitive and functional measures demonstrated better psychometric properties (distribution and test-retest reliability) and stronger associations with AD-related demographic, genetic, and brain risk markers than well-established measures, DISCUSSION: These novel measures have potential for use as primary cognitive and functional outcomes in early-stage AD clinical trials.
Highlights: Well-established cognitive tests may not accurately detect subtle cognitive changes. No Practice Effect (NPE) and Computerized Functional Skills Assessment and Training are novel measures designed to have improved psychometric properties. NPE had Executive Function, Cognitive Control/Speed, and Episodic Memory domains. Novel measures had better psychometric properties compared to established measures. Significant associations with Alzheimer's disease biomarkers were found with novel measures.
논문정보
- Research article
- 2024년 07월 (BRIC 등록일 2024-07-09)
- 국외 연구진
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