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이기윤Gee-Yoon Lee
KAIST
Autophagy, Jul 04 2024, | https://doi.org/10.1080/15548627.2024.2375779
HLH-30/TFEB mediates sexual dimorphism in immunity in caenorhabditis elegans
Jooyeon Sohn 1#, Sujeong Kwon 1#, Gee-Yoon Lee 1#, Sieun S Kim 1, Yujin Lee 1, Jongsun Lee 1, Yoonji Jung 1, Seokjin Ham 1, Hae-Eun H Park 1, Sangsoon Park 1, Seokjun G Ha 1, Daehan Lee 2, Seung-Jae V. Lee 1*
1Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
2Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea.
#contributed equally
*Correspondence : Seung-Jae V. Lee
Abstract
Sexual dimorphism affects various biological functions, including immune responses. However, the mechanisms by which sex alters immunity remain largely unknown. Using
Caenorhabditis elegans as a model species, we showed that males exhibit enhanced immunity against various pathogenic bacteria through the upregulation of HLH-30 (Helix Loop Helix 30/TFEB (transcription factor EB), a transcription factor crucial for macroautophagy/autophagy. Compared with hermaphroditic
C. elegans, males displayed increased activity of HLH-30/TFEB, which contributed to enhanced antibacterial immunity.
atg-2 (AuTophaGy (yeast Atg homolog) 2) upregulated by HLH-30/TFEB mediated increased immunity in male
C. elegans. Thus, the males appear to be equipped with enhanced HLH-30/TFEB-mediated autophagy, which increases pathogen resistance, and this may functionally prolong mate-searching ability with reduced risk of infection.
논문정보
- Research article
- 2024년 07월 (BRIC 등록일 2024-07-05)
- 국내 연구진
- 생명과학 > 노화/암생물학
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