서정목 (연세대학교)

한빛사논문

조회137

연세대학교

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Small, Jun 27 2024, | https://doi.org/10.1002/smll.202402431 Lubricant-Coated Organ-on-a-Chip for Enhanced Precision in Preclinical Drug Testing

Tae Young Kim¹, Jeong-Won Choi ², Kijun Park ¹, SeungHwan Kim³, Jeong F Kim ^3,4, Tae-Eun Park ², Jungmok Seo ^1,5

¹School of Electrical and Electronic Engineering, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

²Department of Biomedical Engineering, College of Information and Biotechnology, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

³Department of Energy and Chemical Engineering, Incheon National University (INU), Incheon, 22012, South Korea.

⁴Innovation Center for Chemical Engineering, Incheon National University (INU), Incheon, 22012, South Korea.

⁵Lynk Solutec lnc, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

T.Y.K. and J.W.C. contributed equally to this work.

CORRESPONDING AUTHORS: Tae-Eun Park,. Jungmok Seo

Abstract

In drug discovery, human organ-on-a-chip (organ chip) technology has emerged as an essential tool for preclinical testing, offering a realistic representation of human physiology, real-time monitoring, and disease modeling. Polydimethylsiloxane (PDMS) is commonly used in organ chip fabrication owing to its biocompatibility, flexibility, transparency, and ability to replicate features down to the nanoscale. However, the porous nature of PDMS leads to unintended absorption of small molecules, critically affecting the drug response analysis. Addressing this challenge, the precision drug testing organ chip (PreD chip) is introduced, an innovative platform engineered to minimize small molecule absorption while facilitating cell culture. This chip features a PDMS microchannel wall coated with a perfluoropolyether-based lubricant, providing slipperiness and antifouling properties. It also incorporates an ECM-coated semi-porous membrane that supports robust multicellular cultures. The PreD chip demonstrates its outstanding antifouling properties and resistance to various biological fluids, small molecule drugs, and plasma proteins. In simulating the human gut barrier, the PreD chip demonstrates highly enhanced sensitivity in tests for dexamethasone toxicity and is highly effective in assessing drug transport across the human blood-brain barrier. These findings emphasize the potential of the PreD chip in advancing organ chip-based drug testing methodologies.

논문정보

형식Research article
게재일2024년 06월 (BRIC 등록일 2024-07-07)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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