양희승 (서울대학교)

한빛사논문

조회323

서울대학교

CV File 51 kb

Proc. Natl. Acad. Sci. USA, Jul 09 2024, 121 (28) | https://doi.org/10.1073/pnas.2320796121 Glial expression of a steroidogenic enzyme underlies natural variation in hitchhiking behavior

Heeseung Yang^a, Daehan Lee^b,c, Heekyeong Kim^d, Daniel E. Cook^b, Young-Ki Paik^d, Erik C. Andersen^b,1, and Junho Lee^a,e,2

^aDepartment of Biological Sciences, Seoul National University,Seoul 08826, Republic of Korea;

^bDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208;

^cDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea;

^dYonsei Proteome Research Center, Yonsei University, Seoul 03722, Republic of Korea; and

^eResearch Institute of Basic Sciences,Seoul National University, Seoul 08826, Republic of Korea

¹Present address: Department of Biology, Johns Hopkins University, Baltimore, MD 21218.

²To whom correspondence may be addressed. : Junho Lee

Abstract

Phoresy is an interspecies interaction that facilitates spatial dispersal by attaching to a more mobile species. Hitchhiking species have evolved specific traits for physical contact and successful phoresy, but the regulatory mechanisms involved in such traits and their evolution are largely unexplored. The nematode Caenorhabditis elegans displays a hitchhiking behavior known as nictation during its stress-induced developmental stage. Dauer-specific nictation behavior has an important role in natural C. elegans populations, which experience boom-and-bust population dynamics. In this study, we investigated the nictation behavior of 137 wild C. elegans strains sampled throughout the world. We identified species-wide natural variation in nictation and performed a genome-wide association mapping. We show that the variants in the promoter of nta-1, encoding a putative steroidogenic enzyme, underlie differences in nictation. This difference is due to the changes in nta-1 expression in glial cells, which implies that glial steroid metabolism regulates phoretic behavior. Population genetic analysis and geographic distribution patterns suggest that balancing selection maintained two nta-1 haplotypes that existed in ancestral C. elegans populations. Our findings contribute to further understanding of the molecular mechanism of species interaction and the maintenance of genetic diversity within natural populations.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-07-04)
연구진국내(교신)+국외 연구진
분야 생명과학 > 세포생물학

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