유승현 (POSTECH)

한빛사논문

조회118

유승현Seung Hyeon Yu

POSTECH

Adv. Sci., Jul 03 2024, | https://doi.org/10.1002/advs.202306256 Alveolar Microdynamics during Tidal Ventilation in Live Animals Imaged by SPring-8 Synchrotron

Min Woo Kim^1,2, Seung Hyeon Yu ³, Un Yang⁴, Ryota Nukiwa⁵, Hyeon Jung Cho ¹, Nam Seop Kwon¹, Moon Jung Yong ⁴, Nam Ho Kim⁴, Sang Hyeon Lee⁴, Jun Ho Lee ⁴, Jae Hong Lim², Yoshiki Kohmura ⁶, Tatsuya Ishikawa⁶, Frank S Henry ⁷, Yumiko Imai⁵, Seung Soo Oh⁴, Hyung Ju Hwang^3,8, Akira Tsuda ^9,10, Jung Ho Je ^1,4,11

¹School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

²Pohang Accelerator Laboratory (PAL), POSTECH, Pohang, 37673, South Korea.

³Department of Mathematics, POSTECH, Pohang, 37673, South Korea.

⁴Department of Materials Science and Engineering, POSTECH, Pohang, 37673, South Korea.

⁵National Institutes of Biomedical Innovation, Health and Nutrition, Infection Medical Information Laboratory, Osaka, 567-0085, Japan.

⁶RIKEN SPring-8 Center, Hyogo, 679-5148, Japan.

⁷Department of Mechanical Engineering, Manhattan College, Riverdale, NY, 10471, USA.

⁸Graduate School of Artificial Intelligence, POSTECH, Pohang, 37673, South Korea.

⁹Department of Environmental Health, Harvard School of Public Health, Boston, MA, 02115, USA.

¹⁰Tsuda Lung Research, Shrewsbury, MA, 01545, USA.

¹¹Nanoblesse Research Lab., Pohang, 37883, South Korea.

M.W.K., S.Y., and U.Y. contributed equally to this work

CORRESPONDING AUTHORS : Akira Tsuda, Jung Ho Je

Abstract

It is self-evident that our chests expand and contract during breathing but, surprisingly, exactly how individual alveoli change shape over the respiratory cycle is still a matter of debate. Some argue that all the alveoli expand and contract rhythmically. Others claim that the lung volume change is due to groups of alveoli collapsing and reopening during ventilation. Although this question might seem to be an insignificant detail for healthy individuals, it might be a matter of life and death for patients with compromised lungs. Past analyses were based on static post-mortem preparations primarily due to technological limitations, and therefore, by definition, incapable of providing dynamic information. In contrast, this study provides the first comprehensive dynamic data on how the shape of the alveoli changes, and, further, provides valuable insights into the optimal lung volume for efficient gas exchange. It is concluded that alveolar micro-dynamics is nonlinear; and at medium lung volume, alveoli expand more than the ducts.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-07-16)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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