한빛사논문
- 조회180
Min Seo Kim,1,2,3,11 Injeong Shim,1,2,3,11 Akl C. Fahed,2,3,4 Ron Do,5,6 Woong-Yang Park,7 Pradeep Natarajan,2,3,4,8 Amit V. Khera,4,9,10,* and Hong-Hee Won1,7,12,*
1Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06355, Republic of Korea
2Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA
3Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
4Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
5The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
6Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
7Samsung Genome Institute, Samsung Medical Center, Seoul 06351, Republic of Korea
8Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
9Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA
10Verve Therapeutics, Boston, MA 02215, USA
11These authors contributed equally
12Lead contact
*Correspondence: Amit V. Khera, Hong-Hee Won
Abstract
The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity and obesity-related morbidities remains unknown. We explored how the interaction between genetic and lifestyle factors influences the risk of obesity and obesity-related morbidities. The polygenic score for body mass index was calculated to quantify inherited susceptibility to obesity in 338,645 UK Biobank European participants, and a composite lifestyle score was derived from five obesogenic factors (physical activity, diet, sedentary behavior, alcohol consumption, and sleep duration). We observed significant interaction between high genetic risk and poor lifestyles (pinteraction < 0.001). Absolute differences in obesity risk between those who adhere to healthy lifestyles and those who do not had gradually expanded with an increase in polygenic score. Despite a high genetic risk for obesity, individuals can prevent obesity-related morbidities by adhering to a healthy lifestyle and maintaining a normal body weight. Healthy lifestyles should be promoted irrespective of genetic background.
논문정보
- Research article
- 2024년 07월 (BRIC 등록일 2024-07-03)
- 국내(교신)+국외 연구진
- 의약학 > 유전 및 유전체의학
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