강희민 (고려대학교)

한빛사논문

조회132

고려대학교

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Adv. Funct. Mater., 26 June 2024 | https://doi.org/10.1002/adfm.202406237 3D-Printed Tissue-Specific Nanospike-Based Adhesive Materials for Time-Regulated Synergistic Tumor Therapy and Tissue Regeneration In Vivo

Hyun Lee^1,2, Ginam Han^1,2, Yuhyun Na^1,2, Minho Kang^1,2, Seo-Jun Bang^1,2, Hyeong Seok Kang³, Tae-Sik Jang⁴, Jung-Hoon Park⁵, Hae Lin Jang⁶, Kisuk Yang⁷, Heemin Kang^8,9, Hyun-Do Jung³

¹Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, 14662 Republic of Korea

²Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662 Republic of Korea

³Division of Materials Science and Engineering, Hanyang University, Seoul, 04763 Republic of Korea

⁴School of Biomedical Convergence Engineering, Pusan National University, Yangsan, 50612 Republic of Korea

⁵Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505 Republic of Korea

⁶Center for Engineered Therapeutics, Department of Medicine and Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA

⁷Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012 Republic of Korea

⁸Department of Materials Science and Engineering, Korea University, Seoul, 02841 Republic of Korea

⁹College of Medicine, Korea University, Seoul, 02841 Republic of Korea

H.L. and G.H. contributed equally to this work.

CORRESPONDING AUTHORS: Heemin Kang, Hyun-Do Jung

Abstract

The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of bone tumors have highlighted the need for multifaceted bone scaffolds that afford tumor therapy, bacterial therapy, and effective vascularized bone reconstruction. However, challenging trilemma has emerged in the realm of bone scaffolds regarding the balance between achieving appropriate mechanical strength, ensuring biocompatibility, and optimizing a degradation rate that aligns with bone-regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing-based nanospikes for the first time. This platform comprises tissue-specific nanospiked hydroxyapatite decorated with magnesium (nMg) and adhesive DNA (aDNA). The incorporation of nMg within polylactic acid (PLA) matrix confers photothermal capabilities and helps to modulate mechanical and degradation properties and improve the biocompatibility of theragenerative platform. Simultaneously, the immobilized aDNA contributed to the enhancement of vascularized bone healing. These 3D-printed tissue-adhesive theragenerative platforms exhibit superior mechanical properties and offer controlled degradability. Moreover, they enable the eradication of bacteria and osteosarcoma through hyperthermia and promote angiogenesis and osteogenesis, both in vitro and in vivo. This groundbreaking approach is poised to pave the way for the fabrication and design of novel implantable biomaterials that integrate therapeutic and regenerative functions.

논문정보

형식Research article
게재일2024년 06월 (BRIC 등록일 2024-07-03)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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