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Exp. Mol. Med., Jul 01 2024, | https://doi.org/10.1038/s12276-024-01261-8
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders
Rajath Ramachandran1, Abdul Manan1, Jei Kim1,2 and Sangdun Choi1,2
1Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
2S&K Therapeutics, Ajou University Campus Plaza 418, 199 Worldcup-ro, Yeongtong-gu, Suwon 16502, Korea.
Corresponding authors
Correspondence to Rajath Ramachandran or Sangdun Choi.
Abstract
Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning of our immune system. When infections or threats to the body's defense mechanisms are detected, the innate immune system takes the lead. However, an excessive inflammatory response can lead to the production of high concentrations of cytotoxic molecules, resulting in tissue damage. Inflammasomes are significant contributors to innate immunity, and one of the most extensively studied inflammasome complexes is NOD-like receptor 3 (NLRP3). NLRP3 has a wide range of recognition mechanisms that streamline immune activation and eliminate pathogens. These cytosolic multiprotein complexes are composed of effector, adaptor, and sensor proteins, which are crucial for identifying intracellular bacterial breakdown products and initiating an innate immune cascade. To understand the diverse behavior of NLRP3 activation and its significance in the development of lifestyle-related diseases, one must delve into the study of the immune response and apoptosis mediated by the release of proinflammatory cytokines. In this review, we briefly explore the immune response in the context of lifestyle associated disorders such as obesity, hyperlipidemia, diabetes, chronic respiratory disease, oral disease, and cardiovascular disease.
논문정보
- Review Paper
- 2024년 07월 (BRIC 등록일 2024-07-02)
- 국내 연구진
- 생명과학 > 면역학
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