이인석 (연세대학교)

한빛사논문

조회227

연세대학교

Exp. Mol. Med., Jul 01 2024, | https://doi.org/10.1038/s12276-024-01262-7 Genome-resolved metagenomics: a game changer for microbiome medicine

Nayeon Kim¹, Junyeong Ma¹, Wonjong Kim¹, Jungyeon Kim¹, Peter Belenky² and Insuk Lee^1,3

¹Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.

²Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

³POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.

Corresponding authors

Correspondence to Peter Belenky or Insuk Lee.

Abstract

Recent substantial evidence implicating commensal bacteria in human diseases has given rise to a new domain in biomedical research: microbiome medicine. This emerging field aims to understand and leverage the human microbiota and derivative molecules for disease prevention and treatment. Despite the complex and hierarchical organization of this ecosystem, most research over the years has relied on 16S amplicon sequencing, a legacy of bacterial phylogeny and taxonomy. Although advanced sequencing technologies have enabled cost-effective analysis of entire microbiota, translating the relatively short nucleotide information into the functional and taxonomic organization of the microbiome has posed challenges until recently. In the last decade, genome-resolved metagenomics, which aims to reconstruct microbial genomes directly from whole-metagenome sequencing data, has made significant strides and continues to unveil the mysteries of various human-associated microbial communities. There has been a rapid increase in the volume of whole metagenome sequencing data and in the compilation of novel metagenome-assembled genomes and protein sequences in public depositories. This review provides an overview of the capabilities and methods of genome-resolved metagenomics for studying the human microbiome, with a focus on investigating the prokaryotic microbiota of the human gut. Just as decoding the human genome and its variations marked the beginning of the genomic medicine era, unraveling the genomes of commensal microbes and their sequence variations is ushering us into the era of microbiome medicine. Genome-resolved metagenomics stands as a pivotal tool in this transition and can accelerate our journey toward achieving these scientific and medical milestones.

논문정보

형식Review Paper
게재일2024년 07월 (BRIC 등록일 2024-07-03)
연구진국내(교신)+국외 연구진
분야 생명과학 > 유전학

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