이평세 (Harvard Medical School / UC Berkeley)

한빛사논문

조회204

Harvard Medical School / UC Berkeley

CV File 956 kb

Nano Converg., Jun 25 2024, 11 (1) | https://doi.org/10.1186/s40580-024-00431-8 Nanoplasmonic sensors for extracellular vesicles and bacterial membrane vesicles

Aparna Neettiyath^1,2†, Kyungwha Chung^1,2,5†, Wenpeng Liu^1,2 and Luke P. Lee^1,2,3,4,5,6*

¹Renal Division and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA

²Harvard Medical School, Harvard University, Boston, MA 02115, USA

³Department of Bioengineering, University of California, Berkeley, CA 94720, USA

⁴Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, USA

⁵Institute of Quantum Biophysics, Department of Biophysics, Sungkyunkwan University, Suwon 16419, Korea

⁶Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea

^†Aparna Neettiyath and Kyungwha Chung contributed equally to this work.

^*Correspondence: Luke P. Lee

Abstract

Extracellular vesicles (EVs) are promising tools for the early diagnosis of diseases, and bacterial membrane vesicles (MVs) are especially important in health and environment monitoring. However, detecting EVs or bacterial MVs presents significant challenges for the clinical translation of EV-based diagnostics. In this Review, we provide a comprehensive discussion on the basics of nanoplasmonic sensing and emphasize recent developments in nanoplasmonics-based optical sensors to effectively identify EVs or bacterial MVs. We explore various nanoplasmonic sensors tailored for EV or bacterial MV detection, emphasizing the application of localized surface plasmon resonance through gold nanoparticles and their multimers. Additionally, we highlight advanced EV detection techniques based on surface plasmon polaritons using plasmonic thin film and nanopatterned structures. Furthermore, we evaluate the improved detection capability of surface-enhanced Raman spectroscopy in identifying and classifying these vesicles, aided by plasmonic nanostructures. Nanoplasmonic sensing techniques have remarkable precision and sensitivity, making them a potential tool for accurate EV detection in clinical applications, facilitating point-of-care molecular diagnostics. Finally, we summarize the challenges associated with nanoplasmonic EV or bacterial MV sensors and offer insights into potential future directions for this evolving field.

논문정보

형식Review Paper
게재일2024년 06월 (BRIC 등록일 2024-06-27)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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