조쌍구 (건국대학교)

한빛사논문

조회162

건국대학교

CV File 4 MB

Nano Converg., Jun 26 2024, 11 (1) | https://doi.org/10.1186/s40580-024-00430-9 Engineering extracellular vesicles for ROS scavenging and tissue regeneration

Ahmed Abdal Dayem¹, Ellie Yan², Minjae Do², Yoojung Kim¹, Yeongseo Lee¹, Ssang-Goo Cho^1,3* and Deok-Ho Kim^2,4,5,6,7,8*

¹Department of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea

²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA

³R&D Team, StemExOne Co., Ltd., 307 KU Technology Innovation Bldg, 120, Neungdong-ro, Gwangjin- gu, Seoul 05029, Republic of Korea

⁴Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA

⁵Department of Medicine, Johns Hopkins University School of Medicine, Baltimore 21205, USA

⁶Center for Microphysiological Systems, Johns Hopkins University, Baltimore, MD 21205, USA

⁷Institute for NanoBiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA

⁸Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

*Correspondence: Ssang-Goo Cho, Deok-Ho Kim

Abstract

Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate critical signaling cascades, thereby facilitating tissue repair. EVs, nano-scale membrane vesicles, mediate intercellular communication by encapsulating a diverse cargo of proteins, lipids, and nucleic acids. Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress-an essential aspect of overcoming limitations in stem cell-based tissue repair. This review focuses on engineering and applying EVs in tissue regeneration, emphasizing their role in regulating reactive oxygen species (ROS) pathways. Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. Understanding these molecular mechanisms is crucial for optimizing EV-based regenerative therapies. Insights into EV and ROS signaling modulation pave the way for targeted and efficient regenerative therapies harnessing the potential of EVs.

논문정보

형식Review Paper
게재일2024년 06월 (BRIC 등록일 2024-06-27)
연구진국내(교신)+국외 연구진
분야 생명과학 > 분자생물학

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