심상희 (서울대학교)

한빛사논문

조회331

서울대학교

CV File 166 kb

Nat. Prod. Rep., Jun 25 2024, | https://doi.org/10.1039/d4np00013g Biosynthesis, biological activities, and structure-activity relationships of decalin-containing tetramic acid derivatives isolated from fungi

Hyun Woo Kim,^a Jin Woo Lee^*b and Sang Hee Shim^*c

^aIntegrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea

^bCollege of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea

^cNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea

^*Corresponding authors : Jin Woo Lee, Sang Hee Shim

Abstract

Covering: up to December 2023Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and antiprotozoal properties, have been the subject of ongoing research. For this reason, these molecules have attracted a lot of interest from the scientific community and various efforts including semi-synthesis, co-culturing with bacteria and biosynthetic gene sequencing have been made to obtain more derivatives. In this review, 3-DTAs are classified into four major groups based on the absolute configuration of the bicyclic decalin ring. Their biosynthetic pathways, various biological activities, and structure-activity relationship are then introduced.

논문정보

형식Review Paper
게재일2024년 06월 (BRIC 등록일 2024-06-27)
연구진국내 연구진
분야 의약학 > 약학

댓글 작성 로그인

CV 열람하기

연락처 보기