한빛사논문
- 조회217
경희대학교
Sunyoung Kim1,34, Hayeon Lee 2,3,34,35, Jinseok Lee 2, Seung Won Lee 4, Rosie Kwon3, Min Seo Kim5, Ai Koyanagi6, Lee Smith7, Guillaume Fond8, Laurent Boyer8, Masoud Rahmati8,9,10, Guillermo F. López Sánchez11, Elena Dragioti12,13, Samuele Cortese14,15,16,17,18, Ju-Young Shin19, Ahhyung Choi19, Hae Sun Suh20,21, Sunmi Lee22, Marco Solmi23,24,25,26, Chanyang Min3, Jae Il Shin27,28,35, Dong Keon Yon3,20,21,29,35 & Paolo Fusar-Poli30,31,32,33
1Department of Family Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
2Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.
3Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
4Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, South Korea.
5Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
6Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain.
7Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
8Research Centre on Health Services and Quality of Life, Assistance Publique-Hôpitaux de Marseille, Aix Marseille University, Marseille, France.
9Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
10Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran.
11Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain.
12Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
13Research Laboratory Psychology of Patients, Families and Health Professionals, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece.
14Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
15Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK.
16Solent NHS Trust, Southampton, UK.
17Child Study Center, Hassenfeld Children’s Hospital at NYU Langone, NYU Langone, New York, NY, USA.
18Department of Precision and Regenerative Medicine and Jonic Area, University of Bari ‘Aldo Moro’, Bari, Italy.
19School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
20Department of Regulatory Science, Kyung Hee University Graduate School, Seoul, South Korea.
21Institute of Regulatory Innovation through Science, Kyung Hee University College of Pharmacy, Seoul, South Korea.
22Department of Applied Mathematics, Kyung Hee University, Yongin, South Korea.
23Department of Psychiatry, SCIENCES lab, University of Ottawa, Ottawa, Ontario, Canada.
24On Track: The Champlain First Episode Psychosis Program, Department of Mental Health, Ottawa Hospital, Ottawa, Ontario, Canada.
25Ottawa Hospital Research Institute Clinical Epidemiology Program, University of Ottawa, Ottawa, Ontario, Canada.
26Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.
27Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea.
28Severance Underwood Meta-Research Center, Institute of Convergence Science, Yonsei University, Seoul, South Korea.
29Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
30Early Psychosis: Interventions and Clinical-Detection Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.
31Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
32Outreach and Support in South-London Service, South London and Maudlsey NHS Foundation Trust, London, UK.
33Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany.
34These authors contributed equally: Sunyoung Kim, Hayeon Lee.
35These authors jointly supervised this work: Hayeon Lee, Jae Il Shin, Dong Keon Yon.
Corresponding authors
Correspondence to Hayeon Lee, Jae Il Shin or Dong Keon Yon.
Abstract
We investigated whether SARS-CoV-2 infection is associated with short- and long-term neuropsychiatric sequelae. We used population-based cohorts from the Korean nationwide cohort (discovery; n = 10,027,506) and the Japanese claims-based cohort (validation; n = 12,218,680) to estimate the short-term (<30 days) and long-term (≥30 days) risks of neuropsychiatric outcomes after SARS-CoV-2 infection compared with general population groups or external comparators (people with another respiratory infection). Using exposure-driven propensity score matching, we found that both the short- and long-term risks of developing neuropsychiatric sequelae were elevated in the discovery cohort compared with the general population and those with another respiratory infection. A range of conditions including Guillain-Barré syndrome, cognitive deficit, insomnia, anxiety disorder, encephalitis, ischaemic stroke and mood disorder exhibited a pronounced increase in long-term risk. Factors such as mild severity of COVID-19, increased vaccination against COVID-19 and heterologous vaccination were associated with reduced long-term risk of adverse neuropsychiatric outcomes. The time attenuation effect was the strongest during the first six months after SARS-CoV-2 infection, and this risk remained statistically significant for up to one year in Korea but beyond one year in Japan. The associations observed were replicated in the validation cohort. Our findings contribute to the growing evidence base on long COVID by considering ethnic diversity.
논문정보
- Research article
- 2024년 06월 (BRIC 등록일 2024-06-26)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 다학제 융합/복합
관련 보도자료
- 팜뉴스
- 2024. 07. 19
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