김영목 (부경대학교)

한빛사논문

조회145

부경대학교

Int. J. Antimicrob. Agents, Jun 20 2024, S0924-8579(24)00161-4 | https://doi.org/10.1016/j.ijantimicag.2024.107243 Strategies for controlling polymicrobial biofilms: a focus on antibiofilm agents

Geum-Jae Jeong ^a,b,c, Fazlurrahman Khan ^b,c,d,e, Nazia Tabassum ^b,c, Kyung-Jin Cho ^a,b,c, Young-Mog Kim ^a,b,c

^aDepartment of Food Science and Technology, Pukyong National University, Busan 48513, Republic of Korea

^bMarine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan, 48513, Republic of Korea

^cResearch Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Republic of Korea

^dInstitute of Fisheries Science, Pukyong National University, Busan 48513, Republic of Korea

^eInternational Graduate Program of Fisheries Science, Pukyong National University, Busan 48513, Republic of Korea

Corresponding authors: Fazlurrahman Khan, Young-Mog Kim

Abstract

Polymicrobial biofilms are among the leading causes of antimicrobial treatment failure. In these biofilms, bacterial and fungal pathogens interact synergistically at the interspecies, intraspecies, and interkingdom levels. Consequently, combating polymicrobial biofilms is substantially more difficult compared to single-species biofilms due to their distinct properties and the resulting potential variation in antimicrobial drug efficiency. In recent years, there has been an increased focus on developing alternative strategies for controlling polymicrobial biofilms formed by bacterial and fungal pathogens. Current approaches for controlling polymicrobial biofilms include monotherapy (using either natural or synthetic compounds), combination treatments, and nanomaterials. Here, a comprehensive review of different types of polymicrobial interactions between pathogenic bacterial species or bacteria and fungi is provided along with a discussion of their relevance. The mechanisms of action of individual compounds, combination treatments, and nanomaterials against polymicrobial biofilms are thoroughly explored. This review provides various future perspectives that can advance the strategies used to control polymicrobial biofilms and their likely modes of action. Since the majority of research on combating polymicrobial biofilms has been conducted in vitro, it would be an essential step in performing in vivo tests to determine the clinical effectiveness of different treatments against polymicrobial biofilms.

논문정보

형식Review Paper
게재일2024년 06월 (BRIC 등록일 2024-06-25)
연구진국내 연구진
분야 생명과학 > 미생물학

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