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서울대학교

Adv. Drug Deliv. Rev., Jun 19 2024, S0169-409X(24)00184-4 | https://doi.org/10.1016/j.addr.2024.115362 Cytoskeleton-modulating nanomaterials and their therapeutic potentials

Jinwon Park ¹, Yina Wu ¹, Jung Suk Kim ¹, Junho Byun, Jaiwoo Lee, Yu-Kyoung Oh

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea

¹These authors equally contributed.

Corresponding authors : Junho Byun, Jaiwoo Lee, Yu-Kyoung Oh

Abstract

The cytoskeleton, an intricate network of protein fibers within cells, plays a pivotal role in maintaining cell shape, enabling movement, and facilitating intracellular transport. Its involvement in various pathological states, ranging from cancer proliferation and metastasis to the progression of neurodegenerative disorders, underscores its potential as a target for therapeutic intervention. The exploration of nanotechnology in this realm, particularly the use of nanomaterials for cytoskeletal modulation, represents a cutting-edge approach with the promise of novel treatments. Inorganic nanomaterials, including those derived from gold, metal oxides, carbon, and black phosphorus, alongside organic variants such as peptides and proteins, are at the forefront of this research. These materials offer diverse mechanisms of action, either by directly interacting with cytoskeletal components or by influencing cellular signaling pathways that, in turn, modulate the cytoskeleton. Recent advancements have introduced magnetic field-responsive and light-responsive nanomaterials, which allow for targeted and controlled manipulation of the cytoskeleton. Such precision is crucial in minimizing off-target effects and enhancing therapeutic efficacy. This review explores the importance of research into cytoskeleton-targeting nanomaterials for developing therapeutic interventions for a range of diseases. It also addresses the progress made in this field, the challenges encountered, and future directions for using nanomaterials to modulate the cytoskeleton. The continued exploration of nanomaterials for cytoskeleton modulation holds great promise for advancing therapeutic strategies against a broad spectrum of diseases, marking a significant step forward in the intersection of nanotechnology and medicine.

논문정보

형식Review Paper
게재일2024년 06월 (BRIC 등록일 2024-06-24)
연구진국내 연구진
분야 의약학 > 약학

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