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Cedars-Sinai Medical Center

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Trends Genet., Jun 21 2024, S0168-9525(24)00132-X | https://doi.org/10.1016/j.tig.2024.05.010 Unveiling contact-mediated cellular crosstalk

Hyobin Kim ^1,7, Kwang-eun Kim ^2,3,7, Esha Madan ^4,5,6, Patrick Martin ¹, Rajan Gogna ^4,5,6, Hyun-Woo Rhee ³, Kyoung-Jae Won¹

¹Department of Computational Biomedicine, Cedars-Sinai Medical Center, West, Hollywood, CA, USA

²Department of Convergence Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea

³Department of Chemistry, Seoul National University, Seoul, South Korea

⁴Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA

⁵School of Medicine, Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, VA, USA

⁶Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA

⁷These authors contributed equally to this work.

Correspondence: Hyun-Woo Rhee, Kyoung-Jae Won

Abstract

Cell-cell interactions orchestrate complex functions in multicellular organisms, forming a regulatory network for diverse biological processes. Their disruption leads to disease states. Recent advancements - including single-cell sequencing and spatial transcriptomics, coupled with powerful bioengineering and molecular tools - have revolutionized our understanding of how cells respond to each other. Notably, spatial transcriptomics allows us to analyze gene expression changes based on cell proximity, offering a unique window into the impact of cell-cell contact. Additionally, computational approaches are being developed to decipher how cell contact governs the symphony of cellular responses. This review explores these cutting-edge approaches, providing valuable insights into deciphering the intricate cellular changes influenced by cell-cell communication.

논문정보

형식Review Paper
게재일2024년 06월 (BRIC 등록일 2024-06-23)
연구진국내(교신)+국외 연구진
분야 생명과학 > 유전학

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