한빛사논문
- 조회306
Sunghwan Kim1, Sheng-Min Wang1, Dong Woo Kang2, Yoo Hyun Um3, Han Min Yoon4, Soyoung Lee5,6, Yeong Sim Choe7, Regina EY Kim7, Donghyeon Kim7, Chang Uk Lee2, Hyun Kook Lim1,8
1Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
2Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
3Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
4Department of Rehabilitation, Yeouido St.Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republicof Korea
5Department of Psychiatry, Brigham and Women’s Hospital, Boston, Massachusetts,USA
6Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
7Research Institute, Neurophet Inc., Seoul ,Republic of Korea
8CMC Institute for Basic Medical Science, the Catholic Medical Center of The Catholic University of Korea, Seoul, Republic of Korea
Correspondence : Hyun Kook Lim
Abstract
Introduction: Despite prior research on the association between sarcopenia and cognitive impairment in the elderly, a comprehensive model that integrates various brain pathologies is still lacking.
Methods: We used data from 528 non-demented older adults with or without sarcopenia in the Catholic Aging Brain Imaging (CABI) database, containing magnetic resonance imaging scans, positron emission tomography scans, and clinical data. We also measured three key components of sarcopenia: skeletal muscle index (SMI), hand grip strength (HGS), and the five times sit-to-stand test (5STS).
Results: All components of sarcopenia were significantly correlated with global cognitive function, but cortical thickness and amyloid-beta (Aβ) retention had distinctive relationships with each measure. In the path model, brain atrophy resulting in cognitive impairment was mediated by Aβ retention for SMI and periventricular white matter hyperintensity for HGS, but directly affected by the 5STS.
Discussion: Treatments targeting each sub-domain of sarcopenia should be considered to prevent cognitive decline.
Highlights: We identified distinct impacts of three sarcopenia measures on brain structure and Aβ. Muscle mass is mainly associated with Aβ and has an influence on the brain atrophy. Muscle strength linked with periventricular WMH and brain atrophy. Muscle function associated with cortical thinning in specific brain regions. Interventions on sarcopenia may be important to ease cognitive decline in the elderly.
논문정보
- Research article
- 2024년 06월 (BRIC 등록일 2024-06-19)
- 국내(교신)+국외 연구진
- 의약학 > 신경의학
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