Jagannath Mondal (한국교통대학교, University of Washington) | 한빛사논문 > 한빛사

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조회214

한국교통대학교, University of Washington

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J. Control. Release, Jun 13 2024, 372 S0168-3659(24)00345-6 | https://doi.org/10.1016/j.jconrel.2024.06.003 Recent advancements of hydrogels in immunotherapy: Breast cancer treatment

Jagannath Mondal ^a,b,h, Kushal Chakraborty ^c, Edwin J. Bunggulawa ^b, Jeong Man An^e, Vishnu Revuri ^b, Md Nurunnabi ^f,g, Yong-Kyu Lee ^a,b,d

^a4D Convergence Technology Institute, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea

^bDepartment of Green Bioengineering, Korea National University of Transportation, Chungju 27470, Republic of Korea

^cDepartment of IT and Energy Convergence (BK21 FOUR), Korea National University of Transportation, Chungju 27469, Republic of Korea

^dDepartment of Chemical & Biological Engineering, Korea National University of Transportation, Chungju 27470, Republic of Korea

^eDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea

^fDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, United States

^gBiomedical Engineering Program, College of Engineering, University of Texas at El Paso, El Paso, TX 79968, United States

^hDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USA

Correspondence to: M. Nurunnabi, Yong-Kyu Lee

Abstract

Breast cancer is the most prevalent cancer among women and the leading cause of cancer-related deaths in this population. Recent advances in Immunotherapy, or combined immunotherapy, offering a more targeted and less toxic approach, expand the survival rate of patients more than conventional treatment. Notably, hydrogels, a versatile platform provided promising avenues to combat breast cancer in preclinical studies and extended to clinical practices. With advantages such as the alternation of tumor microenvironment, immunomodulation, targeted delivery of therapeutic agents, and their sustained release at specific sites of interest, hydrogels can potentially be used for the treatment of breast cancer. This review highlights the advantages, mechanisms of action, stimuli-responsiveness properties, and recent advancements of hydrogels for treating breast cancer immunotherapy. Moreover, post-treatment and its clinical translations are discussed in this review. The integration of hydrogels in immunotherapy strategies may pave the way for more effective, personalized, and patient-friendly approaches to combat breast cancer, ultimately contributing to a brighter future for breast cancer patients.

논문정보

형식Review Paper
게재일2024년 06월 (BRIC 등록일 2024-06-18)
연구진국내(교신)+국외 연구진
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