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- 조회411
Nat. Neurosci., Jun 14 2024, | https://doi.org/10.1038/s41593-024-01683-7
Medial entorhinal cortex mediates learning of context-dependent interval timing behavior
Erin R. Bigus1,3, Hyun-Woo Lee2,3, John C. Bowler2, Jiani Shi2 & James G. Heys2
1Interdepartmental PhD Program in Neuroscience, University of Utah, Salt Lake City, UT, USA.
2Department of Neurobiology, University of Utah, Salt Lake City, UT, USA.
3These authors contributed equally: Erin R. Bigus, Hyun-Woo Lee.
Corresponding author
Correspondence to James G. Heys.
Abstract
Episodic memory requires encoding the temporal structure of experience and relies on brain circuits in the medial temporal lobe, including the medial entorhinal cortex (MEC). Recent studies have identified MEC 'time cells', which fire at specific moments during interval timing tasks, collectively tiling the entire timing period. It has been hypothesized that MEC time cells could provide temporal information necessary for episodic memories, yet it remains unknown whether they display learning dynamics required for encoding different temporal contexts. To explore this, we developed a new behavioral paradigm requiring mice to distinguish temporal contexts. Combined with methods for cellular resolution calcium imaging, we found that MEC time cells display context-dependent neural activity that emerges with task learning. Through chemogenetic inactivation we found that MEC activity is necessary for learning of context-dependent interval timing behavior. Finally, we found evidence of a common circuit mechanism that could drive sequential activity of both time cells and spatially selective neurons in MEC. Our work suggests that the clock-like firing of MEC time cells can be modulated by learning, allowing the tracking of various temporal structures that emerge through experience.
논문정보
- Research article
- 2024년 06월 (BRIC 등록일 2024-06-20)
- 국외 연구진
- 바이오·의료융합 > 뇌인지과학
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