박상민 (서울대학교 의과대학)

한빛사논문

조회173

서울대학교 의과대학

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Psychiatry Res., May 29 2024, 339 S0165-1781(24)00277-4 | https://doi.org/10.1016/j.psychres.2024.115992 Antibiotic exposure and depression incidence: A cohort study of the Korean population

Jaewon Lee ^a,1, Sun Jae Park ^b,1, Seulggie Choi^c, Jooyoung Chang ^b, Young Jun Park ^d, Seogsong Jeong ^e, Joung Sik Son ^f, Gyeongsil Lee ^g,h, Joseph C. Ahn ⁱ, Jihoon Andrew Kim ^j,k, Sang Min Park^b,l

^aDepartment of Psychiatry, University of Rochester, Rochester, NY, USA

^bDepartment of Biomedical Sciences, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea

^cDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea

^dMedical Research Center, Genomic Medicine Institute, Seoul National University, Seoul, South Korea

^eDepartment of Biomedical Informatics, Korea University College of Medicine, Seoul, South Korea

^fDepartment of Internal Medicine, Hanyang University Hospital, Seoul, South Korea

^gDivision of Family Medicine, Life Clinic, Seoul, South Korea

^hKS Healthlink Institute, Seoul, South Korea

ⁱDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, USA

^jDepartment of Psychiatry, Columbia University, New York, NY, USA

^kDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA

^lDepartment of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea

Corresponding author : Sang Min Park

Abstract

Recent research highlights the crucial role of the gut-brain axis in understanding depression etiologies. While burgeoning studies suggest an association between disruptions in gut microbiota and the development of depression, limited longitudinal studies have investigated this link. To address this gap, we conducted a retrospective cohort study using National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data in South Korea, involving 199,144 individuals aged 40-79. We examined the impact of cumulative antibiotic exposure (2004-2008) on subsequent depression incidence (2009-2013) by conducting Cox proportional hazards regressions. Our findings show an increasing depression risk with extended antibiotic exposure after adjusting for comorbidities and behavioral covariates. A broader antibiotic spectrum was associated with a higher depression risk. These trends persisted after adjusting for the original antibiotic indications. In conclusion, our study highlights the duration-dependent association between antibiotic exposure and increased depression risk, offering insights into depression etiologies and relevant novel therapeutic tools, and advocating for heightened antibiotic stewardship considering their impact on mental health.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-06-17)
연구진국내(교신)+국외 연구진
분야 의약학 > 응용의학

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