한빛사
>
한빛사논문
한빛사논문
1
- 조회606
Exp. Mol. Med., Jun 14 2024, | https://doi.org/10.1038/s12276-024-01239-6
Molecular insights into regulatory RNAs in the cellular machinery
Sumin Yang1,3, Sung-Hyun Kim1,3, Eunjeong Yang1, Mingon Kang2 and Jae-Yeol Joo1
1Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
2Department of Computer Science, University of Nevada, Las Vegas, NV 89154, USA.
3These authors contributed equally: Sumin Yang, Sung-Hyun Kim.
Corresponding author
Correspondence to Jae-Yeol Joo.
Abstract
It is apparent that various functional units within the cellular machinery are derived from RNAs. The evolution of sequencing techniques has resulted in significant insights into approaches for transcriptome studies. Organisms utilize RNA to govern cellular systems, and a heterogeneous class of RNAs is involved in regulatory functions. In particular, regulatory RNAs are increasingly recognized to participate in intricately functioning machinery across almost all levels of biological systems. These systems include those mediating chromatin arrangement, transcription, suborganelle stabilization, and posttranscriptional modifications. Any class of RNA exhibiting regulatory activity can be termed a class of regulatory RNA and is typically represented by noncoding RNAs, which constitute a substantial portion of the genome. These RNAs function based on the principle of structural changes through cis and/or trans regulation to facilitate mutual RNA‒RNA, RNA‒DNA, and RNA‒protein interactions. It has not been clearly elucidated whether regulatory RNAs identified through deep sequencing actually function in the anticipated mechanisms. This review addresses the dominant properties of regulatory RNAs at various layers of the cellular machinery and covers regulatory activities, structural dynamics, modifications, associated molecules, and further challenges related to therapeutics and deep learning.
논문정보
- Review Paper
- 2024년 06월 (BRIC 등록일 2024-06-14)
- 국내(교신)+국외 연구진
- 생명과학 > 신경생물학
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
