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Exp. Mol. Med., Jun 03 2024, | https://doi.org/10.1038/s12276-024-01242-x Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway

Kyeong-No Yoon^1,2,3,13, Sun Yong Kim^1,4,13, Jungeun Ji^5,6, Yidan Cui^2,3,7, Qing‐Ling Quan^2,3,7, Gunhyuk Park⁸, Jang-Hee Oh^2,3,7, Ji Su Lee^2,3,7, Joon-Yong An^5,6,9, Jin Ho Chung^1,2,3,7,10, Yong-Seok Lee^1,4,11,12 and Dong Hun Lee^2,3,7

¹Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea.

²Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.

³Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea.

⁴Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.

⁵Department of Integrated Biomedical and Life Science, Korea University, Seoul, Republic of Korea.

⁶BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul, Republic of Korea.

⁷Department of Dermatology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

⁸Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Seoul, Republic of Korea.

⁹School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Republic of Korea.

¹⁰Institute on Aging, Seoul National University, Seoul, Republic of Korea.

¹¹Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

¹²Wide River Institute of Immunology, Seoul National University, Hongcheon, Republic of Korea.

¹³These authors contributed equally: Kyeong-No Yoon, Sun Yong Kim.

Corresponding authors

Correspondence to Jin Ho Chung, Yong-Seok Lee or Dong Hun Lee.

Abstract

The effects of ultraviolet (UV) radiation on brain function have previously been investigated; however, the specific neurotransmitter-mediated mechanisms responsible for UV radiation-induced neurobehavioral changes remain elusive. In this study, we aimed to explore the mechanisms underlying UV radiation-induced neurobehavioral changes. In a mouse model, we observed that UV irradiation of the skin induces deficits in hippocampal memory, synaptic plasticity, and adult neurogenesis, as well as increased dopamine levels in the skin, adrenal glands, and brain. Chronic UV exposure altered the expression of genes involved in dopaminergic neuron differentiation. Furthermore, chronic peripheral dopamine treatments resulted in memory deficits. Systemic administration of a dopamine D1/D5 receptor antagonist reversed changes in memory, synaptic plasticity, adult neurogenesis, and gene expression in UV-irradiated mice. Our findings provide converging evidence that chronic UV exposure alters dopamine levels in the central nervous system and peripheral organs, including the skin, which may underlie the observed neurobehavioral shifts, such as hippocampal memory deficits and impaired neurogenesis. This study underscores the importance of protection from UV exposure and introduces the potential of pharmacological approaches targeting dopamine receptors to counteract the adverse neurological impacts of UV exposure.

논문정보

형식Research article
게재일2024년 06월 (BRIC 등록일 2024-06-13)
연구진국내 연구진
분야 생명과학 > 분자생물학

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