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Weill Cornell Medicine

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Nat. Commun., Jun 11 2024, 15 (1) | https://doi.org/10.1038/s41467-024-49289-8 Spatiotemporal expression and control of haemoglobin in space

Josef Borg ^1,12, Conor Loy ^2,12, JangKeun Kim ^2,12, Alfred Buhagiar ¹, Christopher Chin², Namita Damle ², Iwijn De Vlaminck ², Alex Felice³, Tammy Liu ⁴, Irina Matei ², Cem Meydan ², Masafumi Muratani ⁵, Omary Mzava ⁶, Eliah Overbey ², Krista A. Ryon ², Scott M. Smith ⁷, Braden T. Tierney ², Guy Trudel ⁴, Sara R. Zwart ^7,8, Afshin Beheshti ^9,10,*, Christopher E. Mason ^2,11,*& Joseph Borg^1,*

¹Faculty of Health Sciences, University of Malta, Msida MSD2080, Malta.
²Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
³Department of Surgery, Faculty of Medicine and Surgery, University of Malta, Msida MSD2080, Malta.
⁴Ottawa Hospital Research Institute, Department of Medicine, Ottawa, Ontario, Canada.
⁵Department of Genome Biology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
⁶Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
⁷Biomedical Research and Environmental Sciences Division, Human Health and Performance Directorate, NASA Johnson Space Center, Houston, TX, USA.
⁸University of Texas Medical Branch, Galveston, TX, USA.
⁹Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
¹⁰Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹¹The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10065, USA.
¹²These authors contributed equally: Josef Borg, Conor Loy, JangKeun Kim.

^*Corresponding authors: correspondence to Afshin Beheshti, Christopher E. Mason or Joseph Borg

Abstract

It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homoeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production. Haemoglobin biology provides an intriguing model for studying space omics, as it has been extensively explored at multiple -omic levels, spanning DNA, RNA, and protein analyses, in both experimental and clinical contexts. In this study, we examined the developmental expression of haemoglobin over time and space using a unique suite of multi-omic datasets available on NASA GeneLab, from the NASA Twins Study, the JAXA CFE study, and the Inspiration4 mission. Our findings reveal significant variations in globin gene expression corresponding to the distinct spatiotemporal characteristics of the collected samples. This study sheds light on the dynamic nature of globin gene regulation in response to the space environment and provides valuable insights into the broader implications of space omics research.

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형식Research article
게재일2024년 06월 (BRIC 등록일 2024-06-13)
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