JangKeun Kim ^1,2,36, Braden T. Tierney ^1,2,36, Eliah G. Overbey ^1,2,3,4, Ezequiel Dantas ^5,6, Matias Fuentealba ⁷, Jiwoon Park ^1,2, S. Anand Narayanan ⁸, Fei Wu 7, Deena Najjar ¹, Christopher R. Chin ^2,9,37, Cem Meydan ^1,2,10, Conor Loy ¹¹, Begum Mathyk ¹², Remi Klotz ¹³, Veronica Ortiz ¹³, Khiem Nguyen ⁷, Krista A. Ryon ¹, Namita Damle ¹, Nadia Houerbi ^1,2, Laura I. Patras ^14,15, Nathan Schanzer ¹⁶, Gwyneth A. Hutchinson ^17,18,19, Jonathan Foox ^1,2, Chandrima Bhattacharya ^2,9, Matthew Mackay ⁹, Evan E. Afshin ^1,2, Jeremy Wain Hirschberg ^1,2, Ashley S. Kleinman ^1,2, Julian C. Schmidt ^20,21, Caleb M. Schmidt ^20,21,22, Michael A. Schmidt ^20,21, Afshin Beheshti ^23,24, Irina Matei ^6,14, David Lyden ^6,14, Sean Mullane ²⁵, Amran Asadi ²⁵, Joan S. Lenz ¹¹, Omary Mzava ¹¹, Min Yu ¹³, Saravanan Ganesan ^6,10, Iwijn De Vlaminck ¹¹, Ari M. Melnick ^6,10, Darko Barisic ^6,10, Daniel A. Winer ^{7,26,27,28,29}, Sara R. Zwart ³⁰, Brian E. Crucian ³¹, Scott M. Smith ³¹, Jaime Mateus ²⁴, David Furman ^7,32,33,37,* & Christopher E. Mason ^{1,2,9,34,35,37,*}

¹Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 100221, USA.
²The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.
³Center for STEM, University of Austin, Austin, TX, USA.
⁴BioAstra, Inc, New York, NY, USA.
⁵Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
⁶Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
⁷Buck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA 94945, USA.
⁸Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
⁹Tri-Institutional Biology and Medicine Program, Weill Cornell Medicine, New York, NY 10021, USA.
¹⁰Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
¹¹Cornell University, Meinig School of Biomedical Engineering, Ithaca, NY 14850, USA.
¹²Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
¹³Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
¹⁴Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
¹⁵Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, BabesBolyai University, Cluj-Napoca, Romania.
¹⁶School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
¹⁷NASA Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA 94720, USA.
¹⁸Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
¹⁹Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.
²⁰Sovaris Aerospace, Boulder, CO, USA.
²¹Advanced Pattern Analysis & Human Performance Group, Boulder, CO, USA.
²²Department of Systems Engineering, Colorado State University, Fort Collins, CO, USA.
²³Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
²⁴Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
²⁵Space Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.
²⁶Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
²⁷Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
²⁸Division of Cellular & Molecular Biology, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada.
²⁹Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
³⁰University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA.
³¹Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Human Health and Performance Directorate, 2101 NASA Parkway, Houston, TX 77058, USA.
³²Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA 94306, USA.
³³Instituto de Investigaciones en Medicina Traslacional (IIMT), Universidad Austral, CONICET, Pilar, Argentina.
³⁴The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.
³⁵WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10021, USA.
³⁶These authors contributed equally: JangKeun Kim, Braden T. Tierney.
³⁷These authors jointly supervised this work: David Furman, Christopher E. Mason.

^*Corresponding authors: correspondence to David Furman or Christopher E. Mason