J. Tyson McDonald ^1,32, JangKeun Kim ^2,32, Lily Farmerie ^3,4,32, Meghan L. Johnson ^3,32, Nidia S. Trovao ⁵, Shehbeel Arif ^6,7, Keith Siew ⁸, Sergey Tsoy ⁹, Yaron Bram ⁹, Jiwoon Park ², Eliah Overbey ², Krista Ryon ², Jeffrey Haltom ¹⁰, Urminder Singh ¹¹, Francisco J. Enguita ¹², Victoria Zaksas ^13,14, Joseph W. Guarnieri ¹⁰, Michael Topper ¹⁵, Douglas C. Wallace ^10,16, Cem Meydan ², Stephen Baylin ¹⁵, Robert Meller ¹⁷, Masafumi Muratani ^18,19, D. Marshall Porterfield ²⁰, Brett Kaufman ^3,4, Marcelo A. Mori ^21,22, Stephen B. Walsh ⁸, Dominique Sigaudo-Roussel ²³, Saida Mebarek ²⁴, Massimo Bottini ²⁵, Christophe A. Marquette ²⁶, Eve Syrkin Wurtele ^11,27, Robert E. Schwartz ⁹, Diego Galeano ²⁸, Christopher E. Mason ², Peter Grabham ^29,33,* & Afshin Beheshti ^30,31,33,*

¹Department of Radiation Medicine, Georgetown University School of Medicine, Washington, D.C, USA.
²Department of Physiology, Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine, New York, NY, USA.
³Vascular Medicine Institute at the University of Pittsburgh Department of Medicine, Pittsburgh, PA, USA.
⁴Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.
⁵Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA.
⁶Center for Data-Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA.
⁷Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA, USA.
⁸London Tubular Centre, Department of Renal Medicine, University College London, London, UK.
⁹Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
¹⁰The Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
¹¹Bioinformatics and Computational Biology Program, Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 90011, USA.
¹²Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
¹³Center for Translational Data Science, University of Chicago, Chicago, IL 60637, USA.
¹⁴Clever Research Lab, Springfield, IL 62704, USA.
¹⁵Departments of Oncology and Medicine and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
¹⁶Department of Pediatrics, Division of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
¹⁷Neuroscience Institute, Department of Neurobiology/ Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
¹⁸Transborder Medical Research Center, University of Tsukuba, Ibaraki 305-8575, Japan.
¹⁹Department of Genome Biology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
²⁰Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.
²¹Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.
²²Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, SP, Brazil.
²³LBTI- UMR CNRS 5305, Université Claude Bernard Lyon 1, Lyon, France.
²⁴ICBMS, UMR5246, CNRS, INSA, CPE-Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
²⁵Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
²⁶3d.FAB, CNRS, INSA, CPE-Lyon, UMR5246, ICBMS, Université Claude Bernard Lyon 1, Villeurbanne, France.
²⁷Genetics Program, Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 90011, USA.
²⁸Facultad de Ingeniería, Universidad Nacional de Asunción, San Lorenzo, Paraguay.
²⁹Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
³⁰Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
³¹Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, US.
³²These authors contributed equally: J. Tyson McDonald, JangKeun Kim, Lily Farmerie, Meghan L. Johnson.
³³These authors jointly supervised this work: Peter Grabham, Afshin Beheshti.

^*Corresponding authors: correspondence to Peter Grabham or Afshin Beheshti