박신원 (성균관대학교, Child Mind Institute) | 한빛사논문 > 한빛사

한빛사논문

조회536

박신원Shinwon Park

성균관대학교, Child Mind Institute

인터뷰 보기

Nat. Neurosci., Jun 10 2024, | https://doi.org/10.1038/s41593-024-01679-3 A shifting role of thalamocortical connectivity in the emergence of cortical functional organization

Shinwon Park^1,2, Koen V. Haak^3,4, Stuart Oldham^5,6, Hanbyul Cho¹, Kyoungseob Byeon⁷, Bo-yong Park^1,8, Phoebe Thomson², Haitao Chen^9,10, Wei Gao^9,11, Ting Xu⁷, Sofie Valk^12,13, Michael P. Milham^14,15, Boris Bernhardt¹⁶, Adriana Di Martino² & Seok-Jun Hong^{1,14,17,18,19}

¹Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon, South Korea.

²Autism Center, Child Mind Institute, New York, NY, USA.

³Department of Cognitive Science and Artificial Intelligence, Tilburg School of Humanities and Digital Sciences, Tilburg University, Tilburg, The Netherlands.

⁴Donders Centre for Cognitive Neuroimaging, Donders Institute, Radboud University, Radboud, The Netherlands.

⁵Developmental Imaging, Murdoch Children’s Research Institute, Parkville, Victoria, Australia.

⁶The Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging, Monash University, Clayton, Victoria, Australia.

⁷Center for Integrative Developing Brain, Child Mind Institute, New York, NY, USA.

⁸Department of Data Science, Inha University, Incheon, South Korea.

⁹Department of Biomedical Sciences and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

¹⁰Department of Bioengineering, University of California at Los Angeles, Los Angeles, CA, USA.

¹¹Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

¹²Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

¹³Institute of Neuroscience and Medicine (INM-7), Brain and Behavior, Forschungszentrum, Juelich, Germany.

¹⁴Center for the Developing Brain, Child Mind Institute, New York, NY, USA.

¹⁵Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.

¹⁶McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

¹⁷Department of Biomedical Engineering, Sungkyunkwan University, Suwon, South Korea.

¹⁸Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, South Korea.

¹⁹Department of MetaBioHealth, Sungkyunkwan University, Suwon, South Korea.

Corresponding author

Correspondence to Seok-Jun Hong.

Abstract

The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization in the human brain remains largely unknown. Here we examine age-dependent differences in resting-state thalamocortical connectivity to investigate its role in the emergence of large-scale functional networks during early life, using a primarily cross-sectional but also longitudinal approach. We show that thalamocortical connectivity during infancy reflects an early differentiation of sensorimotor networks and genetically influenced axonal projection. This pattern changes in childhood, when connectivity is established with the salience network, while decoupling externally and internally oriented functional systems. A developmental simulation using generative network models corroborated these findings, demonstrating that thalamic connectivity contributes to developing key features of the mature brain, such as functional segregation and the sensory-association axis, especially across 12-18 years of age. Our study suggests that the thalamus plays an important role in functional specialization during development, with potential implications for studying conditions with compromised internal and external processing.

논문정보

형식Research article
게재일2024년 06월 (BRIC 등록일 2024-06-19)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 뇌인지과학

댓글 작성 로그인

CV 열람하기

연락처 보기