우충완 (성균관대학교, 기초과학연구원) | 한빛사논문 > 한빛사

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성균관대학교, 기초과학연구원

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Proc. Natl. Acad. Sci. USA, Jun 18 2024, 121 (25) | https://doi.org/10.1073/pnas.2310433121 Brain representations of affective valence and intensity in sustained pleasure and pain

Soo Ahn Lee^a,b,c, Jae-Joong Lee^a,1, Jisoo Han^d, Myunghwan Choi^a,e, Tor D. Wager^f, and Choong-Wan Woo^a,b,c,g,1

^aCenter for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, Republic of Korea;

^bDepartment of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea;

^cDepartment of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea;

^dKorea Brain Research Institute, Daegu 41062, Republic of Korea;

^eSchool of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea;

^fDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755; and

^gLife-inspired Neural Network for Prediction and Optimization Research Group, Suwon 16419, Republic of Korea

¹To whom correspondence may be addressed.: Jae-Joong Lee, Choong-Wan Woo

Abstract

Pleasure and pain are two fundamental, intertwined aspects of human emotions. Pleasurable sensations can reduce subjective feelings of pain and vice versa, and we often perceive the termination of pain as pleasant and the absence of pleasure as unpleasant. This implies the existence of brain systems that integrate them into modality-general representations of affective experiences. Here, we examined representations of affective valence and intensity in an functional MRI (fMRI) study ( n = 58) of sustained pleasure and pain. We found that the distinct subpopulations of voxels within the ventromedial and lateral prefrontal cortices, the orbitofrontal cortex, the anterior insula, and the amygdala were involved in decoding affective valence versus intensity. Affective valence and intensity predictive models showed significant decoding performance in an independent test dataset ( n = 62). These models were differentially connected to distinct large-scale brain networks-the intensity model to the ventral attention network and the valence model to the limbic and default mode networks. Overall, this study identified the brain representations of affective valence and intensity across pleasure and pain, promoting a systems-level understanding of human affective experiences.

논문정보

형식Research article
게재일2024년 06월 (BRIC 등록일 2024-06-11)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 뇌인지과학

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