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Adv. Mater., Jun 06 2024, | https://doi.org/10.1002/adma.202404101 Needle-like Multifunctional Biphasic Microfiber for Minimally Invasive Implantable Bioelectronics

Seonghyeon Nam ^1,2, Gi Doo Cha ³, Sung-Hyuk Sunwoo ⁴, Jae Hwan Jeong ⁵, Hyejeong Kang¹, Ok Kyu Park ^1,6, Kyeong-Yeon Lee ⁷, Seil Oh ^7,8, Taeghwan Hyeon ^1,2, Seung Hong Choi ^1,6, Seung-Pyo Lee^1,7,8, Dae-Hyeong Kim²

¹Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.

²School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.

³Department of Systems Biotechnology, Chung-Ang University, Ansung, 17546, Republic of Korea.

⁴Department of Chemical Engineering, Kumoh National Institute of Technology, Gumi, 39177, Republic of Korea.

⁵Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.

⁶Department of Radiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

⁷Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, 03080, Republic of Korea.

⁸Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

S. N., G. D. C., and S.-H. S. contributed equally to this work.

CORRESPONDING AUTHORS: Seung Hong Choi, Seung-Pyo Lee, Dae-Hyeong Kim

Abstract

Implantable bioelectronics has attracted significant attention in electroceuticals and clinical medicine for precise diagnosis and efficient treatment of target diseases. However, conventional rigid implantable devices face challenges such as poor tissue-device interface and unavoidable tissue damage during surgical implantation. Despite continuous efforts to utilize various soft materials to address such issues, their practical applications remain limited. Here, we report a needle-like stretchable microfiber composed of a phase-convertible liquid metal (LM) core and a multifunctional nanocomposite shell for minimally invasive soft bioelectronics. The sharp tapered microfiber can be stiffened by freezing akin to a conventional needle to penetrate soft tissue with minimal incision. Once implanted in vivo where the LM melts, unlike conventional stiff needles, it regains soft mechanical properties, which facilitate a seamless tissue-device interface. The nanocomposite incorporating with functional nanomaterials exhibits both low impedance and the ability to detect physiological pH, providing biosensing and stimulation capabilities. The fluidic liquid metal embedded in the nanocomposite shell enables high stretchability and strain-insensitive electrical properties. This multifunctional biphasic microfiber conforms to the surfaces of the stomach, muscle, and heart, offering a promising approach for electrophysiological recording, pH sensing, electrical stimulation, and radiofrequency ablation in vivo. This article is protected by copyright. All rights reserved.

논문정보

형식Research article
게재일2024년 06월 (BRIC 등록일 2024-06-10)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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