한빛사논문
- 조회368
Laxmanan Karthikeyan a,1, Babu Rithisa b,1, Sunhong Min c, Hyunsik Hong c, Heemin Kang c,d, Ramar Thangam e, Raju Vivek a
aBio-Nano Theranostics Research Laboratory, Cancer Research Program (CRP), School of Life Sciences, Bharathiar University, Coimbatore 641 046, TN, India
bDepartment of Chemistry, Dr. N.G.P Arts and Science College, Coimbatore 641 048, TN, India
cDepartment of Materials Science and Engineering, Korea University, Seoul 02841, Republic of Korea
dCollege of Medicine, Korea University, Seoul 02841, Republic of Korea
eCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
1These authors contribute equally to this work.
Corresponding authors : Heemin Kang, Ramar Thangam, Raju Vivek
Abstract
Polyaniline (PANi), multifunctional organic conjugated polymer, is inexpensive, flexible, and easy to manufacture, while offering a high yield, environmental stability, a high charge transporting capacity, simple redox chemistry, and numerous supramolecular nanostructure designs. For the first time, this review specifically focuses on the advancement of multimodal PANi nanomaterials in the field of biomedicine for its potential applications in nanomedicine, biosensors, tissue engineering, and wound healing, while addressing the limitations and potential biocompatibility and safety regulations to be overcome for clinical translation. In particular, PANi has been employed in photo-theranostics as a component of targeted therapies that destroy tumors via photothermal heat generated by PANi under infrared light illumination. PANi-based photoacoustic imaging also offers real-time therapy monitoring. PANi has also been widely employed in biosensor development, especially for biosensing glucose, peroxide, nucleic acid, cholesterol, immune cytokines, and phenols. In addition, PANi is utilized in tissue engineering applications related to cardiac, nerve, skeletal muscle, and bone tissue. PANi-based nanosystems are also useful for wound-dressing applications. We present a multimodal view of PANi and its physicochemical properties, current research aiming to improve the solubility and biodegradability of PANi, recently emerging applications in biomedical theranostics, and the future challenges that need to be addressed to confirm the clinical utility of this nanomaterial. Overall, the therapeutic multimodality of PANi supramolecular chemistry exhibits considerable potential for use in biomedical research and applications.
논문정보
- Review Paper
- 2024년 05월 (BRIC 등록일 2024-06-10)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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