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University of California, Irvine

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Mol. Cell, Volume 84, Issue 11, 6 June 2024, Pages 2011-2013 | https://doi.org/10.1016/j.molcel.2024.05.0 [Preview] The picky mTORC1 in metabolic enzyme degradation

Yujin Chun¹, David A. Fruman ^2,3, Gina Lee ^1,3

¹Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA, USA

²Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, Irvine, CA, USA

³Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA

Corresponding author : Gina Lee

Abstract

In this issue of Molecular Cell, Yi et al.¹ demonstrate that reduced mTORC1 activity induces the CTLH E3 ligase-dependent degradation of HMGCS1, an enzyme in the mevalonate pathway, thus revealing a unique connection between mTORC1 signaling and the degradation of a specific metabolic enzyme via the ubiquitin-proteasome system.

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게재일2024년 06월 (BRIC 등록일 2024-06-10)
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