한빛사논문
- 조회385
Khai H. Ngoc 1,3, Younghyeon Jeon 1,3, Jaewon Ko 1,2*, Ji Won Um 1,2*
1Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea
2Center for Synapse Diversity and Specificity, DGIST, Daegu 42988, Republic of Korea
3These authors contributed equally to this work.
*Correspondence : Jaewon Ko, Ji Won Um
Abstract
Astrocytes are multifaceted glial cell types that perform structural, functional, metabolic, and homeostatic roles in the brain. Recent studies have revealed mechanisms underlying the diversity of bidirectional communication modes between astrocytes and neurons – the fundamental organizing principle shaping synaptic properties at tripartite synapses. These astrocyte–neuron interactions are critical for the proper functioning of synapses and neural circuits. This review focuses on molecular mechanisms that direct these interactions, highlighting the versatile roles of multiple adhesion-based paths that likely modulate them, often in a context-dependent manner. It also describes how astrocyte-mediated processes go awry in certain brain disorders and provides a timely insight on the pivotal roles of astrocyte–neuron interactions in synaptic integrity and their relevance to understanding and treating neurological disorders.
논문정보
- Review Paper
- 2024년 06월 (BRIC 등록일 2024-06-10)
- 국내 연구진
- 생명과학 > 신경생물학
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