한빛사논문
- 조회366
Daun Jeong a,1, Se Youn Jang b,1, Soonjong Roh b, Ji Hye Choi a, I Ji Seo c, Jin Hyuck Lee d, Jihoon Kim c, Ilkeun Kwon e, Youngmee Jung b,f, Jangsun Hwang a,d*, Woo Young Jang a,d*, Jin Yoo b,g*
aDepartment of Orthopedic Surgery, Korea University College of Medicine, Seoul 02841, Republic of Korea
bBiomaterials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
cAdvanced Biomolecular Recognition Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
dInstitute of Nano, Regeneration, Reconstruction, Korea University, Seoul 02841, Republic of Korea
eDepartment of Dental Materials, School of Dentistry, Kyunghee University, Seoul 02447, Republic of Korea
fSchool of Electrical Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul 03722, Republic of Korea
gDivision of Bio-Medical Science and Technology, KIST school, Korea University of Science and Technology (UST), Seoul 02792, Republic of Korea
1These authors contributed equally to this work.
*Corresponding authors : Jangsun Hwang, Woo Young Jang, Jin Yoo
Abstract
Sprayable hydrogels offer a promising approach for treating diabetic wounds. They possess the capability to conform to irregular surfaces, create a moist environment that supports the growth of new tissue, and offer protection against infections. Yet, applying previously reported sprayable hydrogels has proven to be challenging, often necessitating the use of specialized equipment or the simultaneous injection of multiple components. In this study, we develop a user-friendly therapeutic hydrogel that can be applied using a general spray bottle. This hydrogel is formulated using the bioactive agent, LL37, which is known for its antimicrobial properties and ability to enhance angiogenesis. Additionally, optical mRNA nanosensors, NanoFlares, were incorporated into the hydrogel to measure the expression of proliferation and inflammation biomarkers, providing precise molecular-based parameters for evaluating diabetic wound status. The efficacy of LL37- and NF-incorporated hydrogels in promoting in vivo wound healing in normal and diabetic mice is evaluated, and a Wound Healing Index (WHI) is presented to assist medical professionals in making informed decisions about wound care and treatment. Overall, our study demonstrates the potential of sprayable hydrogels for promoting diabetic wound healing and monitoring the diabetic wound status, which could have significant potential for future clinical applications.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-06-05)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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